Thye, Angel Yun-Kuan and Bah, Yi-Rou and Law, Jodi Woan-Fei and Tan, Loh Teng-Hern and He, Ya-Wen and Wong, Sunny-Hei and Thurairajasingam, Sivakumar and Chan, Kok-Gan and Lee, Learn-Han and Letchumanan, Vengadesh (2022) Gut-skin axis: Unravelling the connection between the gut microbiome and psoriasis. Biomedicines, 10 (5). ISSN 2227-9059, DOI https://doi.org/10.3390/biomedicines10051037.
Full text not available from this repository.Abstract
Evidence has shown that gut microbiome plays a role in modulating the development of diseases beyond the gastrointestinal tract, including skin disorders such as psoriasis. The gut-skin axis refers to the bidirectional relationship between the gut microbiome and skin health. This is regulated through several mechanisms such as inflammatory mediators and the immune system. Dysregulation of microbiota has been seen in numerous inflammatory skin conditions such as atopic dermatitis, rosacea, and psoriasis. Understanding how gut microbiome are involved in regulating skin health may lead to development of novel therapies for these skin disorders through microbiome modulation, in particularly psoriasis. In this review, we will compare the microbiota between psoriasis patients and healthy control, explain the concept of gut-skin axis and the effects of gut dysbiosis on skin physiology. We will also review the current evidence on modulating gut microbiome using probiotics in psoriasis.
| Item Type: | Article |
|---|---|
| Funders: | Jeffrey Cheah School of Medicine and Health Sciences Strategic Grant 2021 [Grant No:STG-000051], External Industry Grant from Biomerge Sdn Bhd [Grant No:BMRG2018-01], University of Malaya Research Grant (FRGS) Grant No:FP022-2018A |
| Uncontrolled Keywords: | Microbiota; Skin Disease; Autoimmune Disease; Probiotic; Gut Dysbiosis |
| Subjects: | Q Science > QH Natural history > QH301 Biology R Medicine > RS Pharmacy and materia medica |
| Divisions: | Faculty of Science > Institute of Biological Sciences |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 10 Oct 2023 04:00 |
| Last Modified: | 10 Oct 2023 04:00 |
| URI: | http://eprints.um.edu.my/id/eprint/42246 |
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