Tune, Bernadette Xin Jie and Sim, Maw Shin and Poh, Chit Laa and Guad, Rhanye Mac and Woon, Choy Ker and Hazarika, Iswar and Das, Anju and Gopinath, Subash C. B. and Rajan, Mariappan and Sekar, Mahendran and Subramaniyan, Vetriselvan and Fuloria, Neeraj Kumar and Fuloria, Shivkanya and Batumalaie, Kalaivani and Wu, Yuan Seng (2022) Matrix Metalloproteinases in Chemoresistance: Regulatory Roles, Molecular Interactions, and Potential Inhibitors. Journal of Oncology, 2022. ISSN 1687-8450, DOI https://doi.org/10.1155/2022/3249766.
Full text not available from this repository.Abstract
Cancer is one of the major causes of death worldwide. Its treatments usually fail when the tumor has become malignant and metastasized. Metastasis is a key source of cancer recurrence, which often leads to resistance towards chemotherapeutic agents. Hence, most cancer-related deaths are linked to the occurrence of chemoresistance. Although chemoresistance can emerge through a multitude of mechanisms, chemoresistance and metastasis share a similar pathway, which is an epithelial-to-mesenchymal transition (EMT). Matrix metalloproteinases (MMPs), a class of zinc and calcium-chelated enzymes, are found to be key players in driving cancer migration and metastasis through EMT induction. The aim of this review is to discuss the regulatory roles and associated molecular mechanisms of specific MMPs in regulating chemoresistance, particularly EMT initiation and resistance to apoptosis. A brief presentation on their potential diagnostic and prognostic values was also deciphered. It also aimed to describe existing MMP in
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Uncontrolled Keywords: | Antineoplastic agent; Gelatinase A; Gelatinase B; Interstitial collagenase; Matrilysin; Matrix metalloproteinase; |
| Subjects: | R Medicine R Medicine > RS Pharmacy and materia medica |
| Divisions: | Faculty of Pharmacy Faculty of Pharmacy > Department of Pharmaceutical Life Sciences |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 09 Nov 2024 03:36 |
| Last Modified: | 09 Nov 2024 03:36 |
| URI: | http://eprints.um.edu.my/id/eprint/42209 |
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