Saleem, Farooq and Mehmood, Rashad and Khan, Tahir Javed and Hassen, Saeed-ul and Maher, Saima and Ahmad, Sarfraz and Perveen, Shagufta and Azeem, Muhammad (2022) Physicochemical and bioassay directed GC-MS analyses of chloroform extract of pteris cretica L. Pharmaceutical Chemistry Journal, 56 (3). pp. 387-395. ISSN 0091-150X, DOI https://doi.org/10.1007/s11094-022-02648-5.
Full text not available from this repository.Abstract
This study was aimed to explore the potential of Pteris cretica L. to be used as herbal remedy. The P. cretica dried plant powder was subjected to a standard physicochemical (proximate analysis) protocol, which showed promising results and was consistent with the WHO recommended ranges that are required to use the plant as a remedy. To identify the bioactive chemical constituents of chloroform extract, the extract was subjected to a series of column chromatography and p-HPLC through the antibacterial and antioxidant bioassays guidance. The two most bioactive sub-fractions of chloroform extract were subjected to GC-MS analysis which revealed the presence of seventeen compounds, the major constituents being eicosane (16.8%), hexadecane (14.1%), methyl hexadecanoate (11.2%), 3,3,8-trimethyldecane (9.1%), 2,6,10-trimethyldodecane (7.8%), tricosane (5.1%) and tetradecane (3.86%). Proximate analysis results show that P. cretica plant is good for herbal remedy, and the bioassay results on chloroform fractions and sub-fractions show that this plant has significant antibacterial and antioxidant potentials. To use this plant as herbal remedy, there is need in further exploration.
| Item Type: | Article |
|---|---|
| Funders: | None |
| Uncontrolled Keywords: | Pteris cretica L; Bioassay guidelines; GC-MS analysis; Proximate analysis; Antibacterial; Antioxidant |
| Subjects: | Q Science > QD Chemistry R Medicine > RM Therapeutics. Pharmacology |
| Divisions: | Faculty of Science > Department of Chemistry |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 19 Oct 2023 02:55 |
| Last Modified: | 19 Oct 2023 02:55 |
| URI: | http://eprints.um.edu.my/id/eprint/42160 |
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