Naomi, Ruth and Bahari, Hasnah and Ong, Zhi Yi and Keong, Yong Yoke and Embong, Hashim and Rajandram, Retnagowri and Teoh, Soo Huat and Othman, Fezah and Hasham, Rosnani and Yin, Khoo Boon and Kaniappan, Priyatharisni and Yazid, Muhammad Dain and Zakaria, Zainul Amiruddin (2022) Mechanisms of natural extracts of andrographis paniculata that target lipid-dependent cancer pathways: A view from the signaling pathway. International Journal of Molecular Sciences, 23 (11). ISSN 1422-0067,
Full text not available from this repository.Abstract
Andrographis paniculata is a local medicinal plant that is widely cultivated in Malaysia. It is comprised of numerous bioactive compounds that can be isolated using water, ethanol or methanol. Among these compounds, andrographolide has been found to be the major compound and it exhibits varieties of pharmacological activities, including anti-cancer properties, particularly in the lipid-dependent cancer pathway. Lipids act as crucial membrane-building elements, fuel for energy-demanding activities, signaling molecules, and regulators of several cellular functions. Studies have shown that alterations in lipid composition assist cancer cells in changing microenvironments. Thus, compounds that target the lipid pathway might serve as potential anti-cancer therapeutic agents. The purpose of this review is to provide an overview of the medicinal chemistry and pharmacology of A. paniculata and its active compounds in terms of anti-cancer activity, primary mechanism of action, and cellular targets, particularly in the lipid-dependent cancer pathway.
| Item Type: | Article |
|---|---|
| Funders: | Long Term Research Grant Scheme of the Malaysia Research University Network [Grant No:6300262-14001], Science and Technology Development Fund (STDF), Ministry of Higher Education & Scientific Research (MHESR) |
| Uncontrolled Keywords: | Natural extract; Cancer; Cellular signaling pathways; Target identification |
| Subjects: | Q Science > QD Chemistry Q Science > QH Natural history > QH301 Biology |
| Divisions: | Faculty of Medicine > Surgery Department |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 11 Oct 2023 07:10 |
| Last Modified: | 11 Oct 2023 07:10 |
| URI: | http://eprints.um.edu.my/id/eprint/42145 |
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