Hor, Jia Wei and Lim, Shen-Yang and Khor, Eng Soon and Chong, Kah Kian and Song, Sze Looi and Ibrahim, Norlinah Mohamed and Teh, Cindy Shuan Ju and Chong, Chun Wie and Hilmi, Ida Normiha and Tan, Ai Huey (2022) Fecal calprotectin in parkinson's disease and multiple system atrophy. Journal of Movement Disorders, 15 (2). 106+. ISSN 2005-940X, DOI https://doi.org/10.14802/jmd.21085.
Full text not available from this repository.Abstract
Objective Converging evidence suggests that intestinal inflammation is involved in the pathogenesis of neurodegenerative diseases. Previous studies on fecal calprotectin in Parkinson's disease (PD) were limited by small sample sizes, and literature regarding intestinal inflammation in multiple system atrophy (MSA) is very scarce. We investigated the levels of fecal calprotectin, a marker of intestinal inflammation, in PD and MSA. Methods We recruited 169 subjects (71 PD, 38 MSA, and 60 age-similar nonneurological controls). Clinico-demographic data were collected. PD and MSA were subtyped and the severity assessed using the MDS-UPDRS and UMSARS, respectively. Fecal calprotectin and blood immune markers were analyzed. Results Compared to controls (median: 35.7 IQR: 114.2] mu g/g), fecal calprotectin was significantly elevated in PD (median: 95.6 IQR: 162.1] mu g/g, p = 0.003) and even higher in MSA (median: 129.5 IQR: 373.8] mu g/g, p = 0.002). A significant interaction effect with age was observed; between-group differences were significant only in older subjects (i.e., >_ 61 years) and became more apparent with increasing age. A total of 28.9% of MSA and 18.3% of PD patients had highly abnormal fecal calprotectin levels (>_ 250 mu g/g); however, this difference was only significant for MSA compared to controls. Fecal calprotectin correlated moderately with selected blood immune markers in PD, but not with clinical features of PD or MSA. Conclusions Elevated fecal calprotectin suggests a role for intestinal inflammation in PD and MSA. A more complete understanding of gut immune alterations could open up new avenues of research and treatment for these debilitating diseases.
| Item Type: | Article |
|---|---|
| Funders: | Ministry of Higher Education, Malaysia Fundamental Research Grant Scheme (FRGS) [Grant No: FRGS/1/2018/SKK02/UM/02/1] |
| Uncontrolled Keywords: | Keywords Fecal calprotectin; Intestinal inflammation; Multiple system atrophy; Parkinson's disease |
| Subjects: | R Medicine > RC Internal medicine R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry |
| Divisions: | Faculty of Medicine Institute of Advanced Studies |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 16 Oct 2023 06:37 |
| Last Modified: | 16 Oct 2023 06:37 |
| URI: | http://eprints.um.edu.my/id/eprint/42106 |
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