Saw, Wen Shang and Anasamy, Theebaa and Do, Thu Thi Anh and Lee, Hong Boon and Chee, Chin Fei and Isci, Umit and Misran, Misni and Dumoulin, Fabienne and Chong, Wu Yi and Kiew, Lik Voon and Imae, Toyoko and Chung, Lip Yong (2022) Nanoscaled PAMAM Dendrimer Spacer Improved the Photothermal-Photodynamic Treatment Efficiency of Photosensitizer-Decorated Confeito-Like Gold Nanoparticles for Cancer Therapy. Macromolecular Bioscience, 22 (8). p. 2200130. ISSN 1616-5187, DOI https://doi.org/10.1002/mabi.202200130.
Full text not available from this repository.Abstract
A critical factor in developing an efficient photosensitizer-gold nanoparticle (PS-AuNP) hybrid system with improved plasmonic photosensitization is to allocate a suitable space between AuNPs and PS. Poly(amidoamine) (PAMAM) dendrimer is selected as a spacer between the PS and confeito-like gold nanoparticles (confeito-AuNPs), providing the required distance (approximate to 2.5-22.5 nm) for plasmon-enhanced singlet oxygen generation and heat production upon 638-nm laser irradiation and increase the cellular internalization of the nanoconjugates. The loading of the PS, tetrakis(4-carboxyphenyl) porphyrin (TCPP), and modified zinc phthalocyanine (ZnPc1) onto PAMAM-confeito-AuNPs demonstrate better in vitro cancer cell-killing efficacy, as the combined photothermal-photodynamic therapies (PTT-PDTs) outperforms the single treatment modalities (PTT or PDT alone). These PS-PAMAM-confeito-AuNPs also demonstrate higher phototoxicity than photosensitizers directly conjugated to confeito-AuNPs (TCPP-confeito-AuNPs and ZnPc1-confeito-AuNPs) against all breast cancer cell lines tested (MDA-MB-231, MCF7, and 4T1). In the in vivo studies, TCPP-PAMAM-confeito-AuNPs are biocompatible and exhibit a selective tumor accumulation effect, resulting in higher antitumor efficacy than free TCPP, PAMAM-confeito-AuNPs, and TCPP-confeito-AuNPs. In vitro and in vivo evaluations confirm PAMAM effectiveness in facilitating cellular uptake, plasmon-enhanced singlet oxygen and heat generation. In summary, this study highlights the potential of integrating a PAMAM spacer in enhancing the plasmon effect-based photothermal-photodynamic anticancer treatment efficiency of PS-decorated confeito-AuNPs.
| Item Type: | Article |
|---|---|
| Funders: | University of Malaya Faculty Research Grant (GPF011C-2018) |
| Uncontrolled Keywords: | dendrimer; gold nanoparticles; photothermal-photodynamic therapy; phthalocyanines; plasmon enhancement; porphyrins; spacer |
| Subjects: | Q Science > QD Chemistry R Medicine > RM Therapeutics. Pharmacology |
| Divisions: | Faculty of Medicine Faculty of Science > Department of Chemistry Deputy Vice Chancellor (Research & Innovation) Office > Nanotechnology & Catalysis Research Centre Deputy Vice Chancellor (Research & Innovation) Office > Photonics Research Centre Faculty of Pharmacy |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 17 Jan 2025 06:59 |
| Last Modified: | 17 Jan 2025 06:59 |
| URI: | http://eprints.um.edu.my/id/eprint/41718 |
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