Yong, Yean Kong and Wong, Won Fen and Vignesh, Ramachandran and Chattopadhyay, Indranil and Velu, Vijayakumar and Tan, Hong Yien and Zhang, Ying and Larsson, Marie and Shankar, Esaki M. (2022) Dengue infection-recent advances in disease pathogenesis in the era of COVID-19. Frontiers in Immunology, 13. ISSN 1664-3224, DOI https://doi.org/10.3389/fimmu.2022.889196.
Full text not available from this repository.Abstract
The dynamics of host-virus interactions, and impairment of the host's immune surveillance by dengue virus (DENV) serotypes largely remain ambiguous. Several experimental and preclinical studies have demonstrated how the virus brings about severe disease by activating immune cells and other key elements of the inflammatory cascade. Plasmablasts are activated during primary and secondary infections, and play a determinative role in severe dengue. The cross-reactivity of DENV immune responses with other flaviviruses can have implications both for cross-protection and severity of disease. The consequences of a cross-reactivity between DENV and anti-SARS-CoV-2 responses are highly relevant in endemic areas. Here, we review the latest progress in the understanding of dengue immunopathogenesis and provide suggestions to the development of target strategies against dengue.
| Item Type: | Article |
|---|---|
| Funders: | Xiamen University Malaysia (Grant No: XMUMRF/2018-C2/ILAB/0001, XMUMRF/2020-C5/ITCM/0003 & XMURF/2018-C1/ENG/0005), United States Department of Health & Human Services National Institutes of Health (NIH) - USA (Grant No: R01AI148377), Emory University CFAR (Grant No: P30 AI050409), United States Department of Health & Human Services National Institutes of Health (NIH) - USA (Grant No: P51 OD011132 & U42 OD011023), Swedish International Development Cooperation Agency, SIDA SARC, Linkoeping University Hospital Research Fund, CALF, Swedish Society of Medicine (Grant No: AI52731), Department of Science and Technology-Science and Engineering Research Board, Government of India (Grant No: CRG/2019/006096) |
| Uncontrolled Keywords: | Dengue (DENV); Pathogenesis; Plasmablasts; Inflammasome; Cytokine storm; Endothelial dysfunction; Antibody-dependent enhancement (ADE); COVID-19 |
| Subjects: | Q Science > QR Microbiology > QR180 Immunology |
| Divisions: | Faculty of Medicine |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 07 Nov 2023 06:04 |
| Last Modified: | 07 Nov 2023 06:04 |
| URI: | http://eprints.um.edu.my/id/eprint/41634 |
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