Loong, Shih Keng and Abd-Majid, Mohamad Azlan and Teoh, Boon Teong and Cheh, Mi Jing and Khor, Chee Sieng and Chao, Chien Chung and Khoo, Jing Jing and AbuBakar, Sazaly (2022) Leptospirosis among dengue-negative febrile patients in Selangor, Malaysia. American Journal of Tropical Medicine and Hygiene, 107 (2). pp. 397-400. ISSN 0002-9637, DOI https://doi.org/10.4269/ajtmh.20-0656.
Full text not available from this repository.Abstract
In recent years, the number of leptospirosis cases, including the number of deaths, has exponentially increased in Malaysia. From June 2016 to February 2018, blood samples of 321 febrile patients with the presumptive diagnosis of dengue-like illness were examined for possible exposure to Leptospira. Two hundred fifty-five blood sam-ples were tested as negative for dengue. Seminested polymerase chain reaction (PCR) and IgM ELISA for leptospirosis were performed. From the samples, an overall prevalence for leptospirosis based on PCR of 4.7% (12/255) was obtained. Eighteen percent (46/255) were positive for anti-Leptospira IgM antibodies. The genome sequences of six of 12 Leptospira PCR-positive samples showed > 97.0% similarity to Leptospira interrogans. One patient's sample con-sisted of Leptospira and chikungunya virus, suggesting a coinfection. Findings from the study suggest that leptospirosis is prevalent among dengue-negative febrile patients in Malaysia.
| Item Type: | Article |
|---|---|
| Funders: | Ministry of Education, Malaysia [MO002-2019] |
| Uncontrolled Keywords: | Epidemiology; Diagnosis |
| Subjects: | R Medicine |
| Divisions: | Deputy Vice Chancellor (Research & Innovation) Office > Tropical Infectious Diseases Research and Education Centre |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 21 Sep 2023 04:23 |
| Last Modified: | 21 Sep 2023 04:23 |
| URI: | http://eprints.um.edu.my/id/eprint/41382 |
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