Lai, Nicole Jean-Yean and Ngu, Ee-Ling and Pang, Jun-Rui and Wong, Kah Hui and Ardianto, Chrismawan and Ming, Long Chiau and Lim, Siew Huah and Walvekar, Shweta Gangasa and Anwar, Ayaz and Yow, Yoon-Yen (2022) Carrageenophyte kappaphycus malesianus inhibits microglia-mediated neuroinflammation via suppression of AKT/NF-kappa B and ERK signaling pathways. Marine Drugs, 20 (8). ISSN 1660-3397, DOI https://doi.org/10.3390/md20080534.
Full text not available from this repository.Abstract
Neuroinflammation is an inflammatory response in any part of the central nervous system triggered by the activation of microglia and astrocytes to produce proinflammatory cytokines in the brain. However, overproduction of proinflammatory cytokines further contributes to the development of neurodegenerative disorders. Red seaweed, Kappaphycus malesianus, is a predominant carrageenophyte commercially cultivated in Semporna, Sabah, Malaysia. It is an important source of raw material for kappa-carrageenan productions in the food, pharmaceutical and cosmetics industries. However, no studies have been conducted focusing on the antineuroinflammatory effects of K. malesianus. The aim of the present study was to investigate the effect of the antineuroinflammatory activity of K. malesianus extracts (ethyl acetate, ethanol and methanol) on lipopolysaccharide-stimulated BV2 microglia and the underlying mechanisms involved in the regulation of neuroinflammatory pathways. Extract with the most promising antineuroinflammatory activity was analyzed using liquid chromatography-mass spectrometry (LC-MS). Our results show that methanol extract has a convincing antineuroinflammatory effect by suppressing both AKT/NF-kappa B and ERK signaling pathways to inhibit the expression of all proinflammatory cytokines without causing a cytotoxicity effect. LC-MS analysis of methanol extract revealed two compounds: prosopinine and eplerenone. Our findings indicated that metabolites of K. malesianus are potent antineuroinflammatory agents with respect to prevention of neurological disorders.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Uncontrolled Keywords: | Red seaweed; BV2 microglia; Antineuroinflammatory; Neuroprotective; Proinflammatory cytokines; Local breeds; Sustainable |
| Subjects: | Q Science > QD Chemistry R Medicine R Medicine > RM Therapeutics. Pharmacology |
| Divisions: | Faculty of Medicine |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 21 Sep 2023 04:16 |
| Last Modified: | 21 Sep 2023 04:16 |
| URI: | http://eprints.um.edu.my/id/eprint/41381 |
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