Wahabi, Janatul Madinah and Hanifah, Noor Zati Hani Abu and Hashim, Suhairul and Bradley, D. A. (2022) Modified irradiation technique for transfusable blood using a clinical linear accelerator. Radiation Physics and Chemistry, 200 (SI). ISSN 0969-806X, DOI https://doi.org/10.1016/j.radphyschem.2022.110277.
Full text not available from this repository.Abstract
Whole blood irradiation prior to blood transfusion mitigates the risk of Transfusion Associated Graft versus Host Disease (TA-GvHD) to the receiver. This study aimed to improve dose homogeneity, also to benefit from a faster technique and a simplified blood irradiation workflow. An acrylic box accommodating eight units of blood has been fabricated, build-up material being used to ensure dose homogeneity. A linear accelerator dose distribution treatment plan for blood bag irradiations has been evaluated, measurement of dose using nanoDot optically stimulated luminescent dosimeters (OSLD) allowing comparison with calculated dose. By using build-up mate-rial, dose distribution was within 95%-107% of the prescribed dose. With all eight units of blood accommodated in the box, an irradiation time of 20 min per box has been needed. Compared to a previously adopted procedure, use of the acrylic box and build-up material maintains dose homogeneity, also simplifying the workflow, the technique also being easy to undertake by the operators.
| Item Type: | Article |
|---|---|
| Funders: | Ministry of Education, Malaysia, Universiti Teknologi Malaysia through the FRGS grant, Department of Radiotherapy and Oncology, Hospital Sultan Ismail, Johor Bahru and Ministry of Health Malaysia (FRGS/1/2019/STG02/UTM/02/3) |
| Uncontrolled Keywords: | Blood irradiation; Radiotherapy; OSLD; TA-GvHD |
| Subjects: | Q Science > QC Physics Q Science > QD Chemistry R Medicine |
| Divisions: | Faculty of Medicine > Biomedical Imaging Department |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 18 Jul 2023 08:31 |
| Last Modified: | 18 Jul 2023 08:31 |
| URI: | http://eprints.um.edu.my/id/eprint/41047 |
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