Othman, Noor Aimi and Liew, Sook Yee and Blanchard, Patricia and Derbre, Severina and Chong, Soon-Lim and Ali, Abdul Manaf and Awang, Khalijah (2022) (+)-Neocadambine A and (-)-nauclederine isolated from the bark of Neolamarckia cadamba (Rubiaceae) as natural advanced glycation end products (AGEs) inhibitors. Sains Malaysiana, 51 (6). pp. 1725-1732. ISSN 0126-6039, DOI https://doi.org/10.17576/jsm-2022-5106-10.
Full text not available from this repository.Abstract
The phytochemical study on the dichloromethane extract of Neolamarckia cadamba (Roxb.) Bosser has afforded two indole alkaloids, (+)-neocadambine A (1) and (-)-nauclederine (2). Their structures were confirmed by extensive spectroscopic analysis and by comparing with the reported data. (+)-Neocadambine A (1) and (-)-nauclederine (2) exhibited potent inhibition activity of advanced glycation end products (AGEs) with IC50 values of 1.2 and 0.95 mM, respectively, while the latter was almost two times more potent than the standard, aminoguanidine (1.8 mM). This is the first report on the compounds isolated from this plant with AGEs inhibition activity. In addition, (-)-nauclederine (2) was isolated for the first time in the genus of Neolamarckia. Complete 1H-NMR and 13C-NMR of compound 2 were also reported.
| Item Type: | Article |
|---|---|
| Funders: | Universiti Malaya, French Embassy in Malaysia, Fundamental Research Grant Scheme [Grant no. FRGS/1/2018/STG01/UM/02/16] |
| Uncontrolled Keywords: | Advanced glycation end products; Indole alkaloid; (-)-Nauclederine; (+)-Neocadambine A; Neolamarckia cadamba |
| Subjects: | Q Science > QD Chemistry |
| Divisions: | Faculty of Science > Department of Chemistry |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 05 Aug 2025 04:35 |
| Last Modified: | 05 Aug 2025 04:35 |
| URI: | http://eprints.um.edu.my/id/eprint/40980 |
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