Nathan, Anna Marie and Chong, Kai Ning and Teh, Cindy Shuan Ju and Hng, Shih Ying and Eg, Kah Peng and de Bruyne, Jessie Anne and Muhamad, Anis Najwa and Adam, Quraisiah and Zaki, Rafdzah Ahmad and Razali, Nuguelis (2022) Colonization of the newborn respiratory tract and its association with respiratory morbidity in the first 6 months of life: A prospective cohort study. International Journal of Infectious Diseases, 122. pp. 712-720. ISSN 1201-9712, DOI https://doi.org/10.1016/j.ijid.2022.06.049.
Full text not available from this repository.Abstract
Objectives: We aimed to determine the association between newborn bacterial colonization and infant respiratory morbidity in the first 6 months of life. Methods: This prospective study included healthy newborn infants. Nasopharyngeal swabs performed within 72 hours of delivery were analyzed using polymerase chain reaction. We assessed cumulative respiratory morbidity of infants at 6 months. Results: A total of 426 mother-infant pairs were recruited. In 53.3% (n = 225) of newborns, Streptococcus pneumoniae (46%) and Staphylococcus aureus (7.3%) were isolated. None had Haemophilus influenzae nor Moraxella catarrhalis. At the age of 6 months, 50.7% of infants had experienced respiratory symptoms, 25% had unscheduled doctor visits, and 10% were treated with nebulizers. Colonization with S. pneumoniae was associated with reduced risk of any respiratory symptom (adjusted odds ratio aOR] 0.39, 95% confidence interval CI] 0.16, 0.50), unscheduled doctor visits (aOR 0.35; 95% CI 0.18, 0.67), and nebulizer treatment (aOR 0.23, 95% CI 0.07, 0.72) at 6 months. Pregnancy-induced hypertension was also associated with increased need for nebulizer treatment (aOR 9.11, 95% CI 1.43, 58.1). Conclusion: Colonization of the newborn respiratory tract occurred in 53% of infants. S. pneumoniae was the most common organism, and this was associated with a reduced risk for respiratory morbidity at 6 months of life. (c) 2022 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
| Item Type: | Article |
|---|---|
| Funders: | Malaysian Thoracic Society, Malaysia, Universiti Malaya [RK-003-2020] |
| Uncontrolled Keywords: | Malaysia; Child; Respiratory tract; Infection; Streptococcus; Staphylococcus |
| Subjects: | R Medicine R Medicine > RJ Pediatrics |
| Divisions: | Faculty of Medicine |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 28 Aug 2023 01:24 |
| Last Modified: | 28 Aug 2023 01:24 |
| URI: | http://eprints.um.edu.my/id/eprint/40938 |
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