Rashidah, Nur Hannah and Lim, Siong Meng and Neoh, Chin Fen and Majeed, Abu Bakar Abdul and Tan, Maw Pin and Khor, Hui Min and Tan, Ai Huey and Rehiman, Siti Hajar and Ramasamy, Kalavathy (2022) Differential gut microbiota and intestinal permeability between frail and healthy older adults: A systematic review. Ageing Research Reviews, 82. ISSN 1568-1637, DOI https://doi.org/10.1016/j.arr.2022.101744.
Full text not available from this repository.Abstract
This systematic review appraised previous findings on differential gut microbiota composition and intestinal permeability markers between frail and healthy older adults. A literature search was performed using PubMed, Scopus, ScienceDirect and the Cochrane Library. Relevant studies were shortlisted based on inclusion and exclusion criteria as well as assessed for risk of bias. The primary outcome was the differential composition of gut microbiota and/ or intestinal permeability markers between frail and healthy older adults. A total of 10 case -control studies and one cohort study were shortlisted. Based on consistent findings reported by more than one shortlisted study, the microbiota of frail older adults was characterised by decreased phylum Firmicutes, with Dialister, Lactobacillus and Ruminococcus being the prominent genera. Healthy controls, on the other hand, exhibited higher Eubacterium at the genera level. In terms of intestinal permeability, frail older adults were presented with increased serum zonulin, pro-inflammatory cytokines (TNF-alpha, HMGB-1, IL-6, IL1-ra, MIP-1 beta) and amino acids (aspartic acid and phosphoethanolamine) when compared to healthy controls. Altogether, frail el-derlies had lower gut microbiota diversity and lower abundance of SCFA producers, which may have led to leaky guts, upregulated pro-inflammatory cytokines, frailty and sarcopenia.
| Item Type: | Article |
|---|---|
| Funders: | Ministry of Education, Malaysia [600-RMC/LRGS 5/3 (002/2019)] |
| Uncontrolled Keywords: | Aged; Frailty; Gut microbiota; Leaky gut; Inflammaging |
| Subjects: | R Medicine > R Medicine (General) |
| Divisions: | Faculty of Medicine |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 27 Sep 2023 06:26 |
| Last Modified: | 27 Sep 2023 06:26 |
| URI: | http://eprints.um.edu.my/id/eprint/40793 |
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