Deroepidemiology of toxoplasmosis in renal patients

Nissapatorn, V. and Leong, T.H. and Lee, R. and Init, I. and Ibrahim, J. and Yen, T.S. (2011) Deroepidemiology of toxoplasmosis in renal patients. Southeast Asian Journal of Tropical Medicine and Public Health, 42 (2). pp. 237-247. ISSN init@um.edu.my, DOI 21710842.

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Abstract

Toxoplasmosis is an important parasitic disease in immunosuppressed patients. This prospective study was conducted to determine the seroprevalence, associated risk factors and the incidence of clinically confirmed toxoplasmosis among renal patients at the University of Malaya Medical Center, Kuala Lumpur, Malaysia. We interviewed 247 renal patients, each of whom answered an epidemiological questionnaire, and collected blood samples for measurement of anti-Toxoplasma IgG and IgM antibodies by ELISA. Overall seroprevalence of latent toxoplasmosis was observed in 126 (51) renal patients. Race (Malays), marital status (married) and primary level of education, were all factors associated with a greater chance of Toxoplasma infection. A case of clinically confirned toxoplasmosis was diagnosed in a renal transplant recipient as a result of immunosuppression. Based on the findings obtained, this preliminary study shows a high prevalence of latent toxoplasmosis in renal patients. Risk factors may have significantly contributed to Toxoplasma acquisition in these patients. We recommend further studies be carried out to monitor for trends in toxoplasmosis among immunosuppressed patients.

Item Type:	Article
Funders:	UNSPECIFIED
Additional Information:	Nissapatorn, Veeranoot Leong, Teoh Hoe Lee, Rogan Init-Ithoi Ibrahim, Jamaiah Yen, Tan Si eng Research Support, Non-U.S. Gov't Thailand 2011/06/30 06:00 Southeast Asian J Trop Med Public Health. 2011 Mar;42
Uncontrolled Keywords:	Adult Age Factors Aged Aged, 80 and over Animals Antibodies/blood Blood Transfusion/adverse effects Cats Continental Population Groups Cooking Cross-Sectional Studies Eating Educational Status Female Humans Kidney Failure, Chronic/*complications Malaysia/epidemiology Male Marital Status Meat/parasitology Middle Aged Prevalence Prospective Studies Risk Factors Seroepidemiologic Studies Toxoplasma/isolation & purification Toxoplasmosis/*complications/*epidemiology/parasitology Young Adult
Subjects:	R Medicine
Divisions:	Faculty of Medicine
Depositing User:	Mr Jenal S
Date Deposited:	06 Dec 2012 06:52
Last Modified:	06 Dec 2012 06:52
URI:	http://eprints.um.edu.my/id/eprint/4078

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