Apparoo, Yasaaswini and Phan, Chia Wei and Kuppusamy, Umah Rani and Sabaratnam, Vikneswary (2022) Ergothioneine and its prospects as an anti-ageing compound. Experimental Gerontology, 170. ISSN 0531-5565, DOI https://doi.org/10.1016/j.exger.2022.111982.
Full text not available from this repository.Abstract
Healthy ageing is a crucial process that needs to be highlighted as it affects the quality of lifespan. An increase in oxidative stress along with ageing is the major factor related to the age-associated diseases, especially neuro-degenerative disorders. An antioxidant-rich diet has been proven to play a significant role in the ageing process. Targeting ageing mechanisms could be a worthwhile approach to improving health standards. Ergothioneine (EGT), a hydrophilic compound with specific transporter known as OCTN1, has been shown to exert anti-ageing properties. In addition to its antioxidant effect, EGT has been reported to have anti-senescence, anti-inflam-matory and anti-neurodegenerative properties. This review aims to define the pivotal role of EGT in major signalling pathways in ageing such as insulin/insulin-like growth factor (IGF) signalling (IIS), sirtuin 6 (SIRT6) and mammalian target of rapamycin complex (mTOR) pathways. The review further discusses evidence of EGT on neurodegeneration in its therapeutic context in various model organisms, providing new insights into improving health. In conclusion, an ergothioneine-rich diet may be beneficial in preventing age-related diseases, resulting in a healthy ageing population.
| Item Type: | Article |
|---|---|
| Funders: | Ministry of Higher Education, Malaysia [Grant no. FP016-2019A, FRGS/1/2019/SKK09/UM/02/2] |
| Uncontrolled Keywords: | Ageing; Ergothioneine; Mitochondrial dysfunction; Oxidative stress; Neurodegenerative diseases |
| Subjects: | Q Science > QH Natural history > QH301 Biology R Medicine > RS Pharmacy and materia medica |
| Divisions: | Faculty of Medicine > Biomedical Science Department Faculty of Science > Institute of Biological Sciences Faculty of Pharmacy > Department of Pharmaceutical Life Sciences |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 11 Sep 2025 04:23 |
| Last Modified: | 11 Sep 2025 04:23 |
| URI: | http://eprints.um.edu.my/id/eprint/40773 |
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