Primus, Phoebe Sussana and Ismail, Muhammad Hazran and Adnan, Nabila Elyana and Wu, Carol Hsin-Yi and Kao, Chao-Lin and Choo, Yeun-Mun (2022) Chemical constituents and anti-neuroblastoma activity from boesenbergia stenophylla. Sains Malaysiana, 51 (4). pp. 1075-1084. ISSN 0126-6039, DOI https://doi.org/10.17576/jsm-2022-5104-10.
Full text not available from this repository.Abstract
Three diarylheptanoids and one flavonoid, i.e. 7-(4-hydroxy-3-methoxyphenyl)-1-phenylhept-4-en-3-one (4), 5R-hydroxy-7-(4-hydroxy-3-methoxy phenyl)-1-phenylheptan-3-o ne (5), 1,7-diphenylhept-4-en-3-one (6), and 3,5,7-trihydroxyflavone (7) were isolated and characterized from the rhizome of Boesenbergia stenophylla. Compounds 2 and 4 displayed excellent anti-neuroblastoma activity which reduces the cell viability to 30% and 20%, respectively. The results from the molecular docking experiments targeting the protein kinases regulating neuroblastoma cell survival (PI3K/AKT1 signalling pathway) are consistent with that of the in vitro results. Finally, the structures of 4-7 were elucidated using spectroscopic methods (UV, IR, NMR, and HRESIMS).
| Item Type: | Article |
|---|---|
| Funders: | Universiti Malaya [Grant No: GPF055B-2018; ST004-2018; ST008-2020] |
| Uncontrolled Keywords: | AKT1; Anti-neuroblastoma; Boesenbergia stenophylla; N2A; PI3K |
| Subjects: | Q Science > Q Science (General) Q Science > QD Chemistry |
| Divisions: | Faculty of Science > Department of Chemistry |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 30 Sep 2025 07:44 |
| Last Modified: | 30 Sep 2025 07:44 |
| URI: | http://eprints.um.edu.my/id/eprint/40452 |
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