Chee, Cheok Wui and Zamakshshari, Nor Hisam and Lee, Vannajan Sanghiran and Abdullah, Iskandar and Othman, Rozana and Lee, Yean Kee and Hashim, Najihah Mohd and Rashidid, Nurshamimi Nor (2022) Morindone from Morinda citrifolia as a potential antiproliferative agent against colorectal cancer cell lines. PLoS ONE, 17 (7). ISSN 1932-6203, DOI https://doi.org/10.1371/journal.pone.0270970.
Full text not available from this repository.Abstract
There is an increasing demand in developing new, effective, and affordable anti-cancer against colon and rectal. In this study, our aim is to identify the potential anthraquinone compounds from the root bark of Morinda citrifolia to be tested in vitro against colorectal cancer cell lines. Eight potential anthraquinone compounds were successfully isolated, purified and tested for both in-silico and in-vitro analyses. Based on the in-silico prediction, two anthraquinones, morindone and rubiadin, exhibit a comparable binding affinity towards multitargets of beta-catenin, MDM2-p53 and KRAS. Subsequently, we constructed a 2D interaction analysis based on the above results and it suggests that the predicted anthraquinones from Morinda citrifolia offer an attractive starting point for potential antiproliferative agents against colorectal cancer. In vitro analyses further indicated that morindone and damnacanthal have significant cytotoxicity effect and selectivity activity against colorectal cancer cell lines.
| Item Type: | Article |
|---|---|
| Funders: | None |
| Uncontrolled Keywords: | Anticancer activity; Damnacanthal; Anthraquinones; P53; Pharmacophore; Inhibitors; Apoptosis; Protein; Drugs; Diet |
| Subjects: | R Medicine > RM Therapeutics. Pharmacology |
| Divisions: | Faculty of Medicine > Department of Molecular Medicine Faculty of Science > Department of Chemistry Centre for Natural Products Research and Drug Discovery (CENAR) Faculty of Pharmacy |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 15 Jul 2024 08:13 |
| Last Modified: | 16 Jul 2024 07:25 |
| URI: | http://eprints.um.edu.my/id/eprint/40439 |
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