Albaayit, Shaymaa Fadhel Abbas and Abdullah, Rasedee and Noor, Mohd Hezmee Mohd (2022) Zerumbone-loaded nanostructured lipid carrier gel enhances wound healing in diabetic rats. BioMed Research International, 2022. ISSN 2314-6133, DOI https://doi.org/10.1155/2022/1129297.
Full text not available from this repository.Abstract
This study investigated the healing effects of topical application of zerumbone, a well-known anti-inflammatory compounds loaded on nanostructured lipid carrier gel (Carbopol 940) (ZER-NLCG) on excisional wounds in streptozotocin-induced diabetic rats. Diabetic rats with inflicted superficial skin wound were topically treated with ZER-NLCG, empty NLCG, and silver sulfadiazine cream (SSDC) once daily for 21 days. Wound tissue samples were analyzed for proinflammatory cytokines, namely, interleukin-6 (IL-6), interleukin-1 ss (IL-1 ss), and tumor necrosis factor-alpha (TNF-alpha), hydroxyproline contents, catalase, superoxide dismutase activities, and lipid peroxidation level, and were subjected to histopathological analysis, respectively. Among the treated groups, ZER-NLCG was the most effective at decreasing proinflammatory cytokine level and inflammatory cell infiltration while increasing antioxidant enzyme activities, hydroxyproline content, and granulation of wound tissues of diabetic rats. ZER-NLCG is a potent formulation for the enhancement of wound healing in diabetic rats through its antiinflammatory, antioxidant, and tissue repair activities.
| Item Type: | Article |
|---|---|
| Funders: | Universiti Malaya [PG059-2013A] |
| Uncontrolled Keywords: | ANGIOGENESIS; EXTRACT; REPAIR |
| Subjects: | Q Science > QR Microbiology S Agriculture > S Agriculture (General) |
| Divisions: | Faculty of Science > Institute of Biological Sciences |
| Depositing User: | Ms. Juhaida Abd Rahim |
| Date Deposited: | 15 Jul 2024 06:32 |
| Last Modified: | 15 Jul 2024 06:32 |
| URI: | http://eprints.um.edu.my/id/eprint/40420 |
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