Nisaa, Azka Ainun and Oon, Chern-Ein and Sreenivasan, Sasidharan and Balakrishnan, Venugopal and Tan, Jun Jie and Teh, Cindy Shuan Ju and Sany, Salina and Todorov, Svetoslav Dimitrov and Liu, Guoxia and Park, Yong-Ha and Liong, Min-Tze (2023) Breast milk from healthy women has higher anti-Candida properties than women with vaginal infections during pregnancy. Food Science and Biotechnology, 32 (4, SI). pp. 471-480. ISSN 1226-7708, DOI https://doi.org/10.1007/s10068-022-01088-x.
Full text not available from this repository.Abstract
The aim of this study was to investigate the different immunological and antimicrobial properties of breast milk from women with (W) or without (WO) vaginal yeast infections during pregnancy in 85 lactating women (W, n = 43; WO, n = 42). Concentrations of IL-10, IgA, IgM, IgG, EGF, and TGF-alpha were similar in both groups. However, breast milk of women aged below 31 years old from the W-group showed higher concentration of EGF than the WO-group (p = 0.031). Breast milk from WO-group exhibited higher anti-Candida properties than W-group, both via growth inhibition and aggregation of yeast cells (p < 0.001). Correlation analysis showed that breast milk concentration of TGF-alpha positively correlated with concentrations of IL-10 (p = 0.001) and IgA (p = 0.021) in the W-group. Data from our present study shows that although breast milk from women with vaginal infections during pregnancy may not sufficiently hinder Candida growth, other immuno-modulatory bioactives may substitute for such a protective effect.
| Item Type: | Article |
|---|---|
| Funders: | USM-Probionic Grant (304/PTEKIND/6501096), USM-Industry Research Matching Grant (1001/PTEKIND/8070012) |
| Uncontrolled Keywords: | Breast milk; Vaginal infections; Pregnant women; Immuno-modulation; Anti-Candida |
| Subjects: | Q Science > Q Science (General) R Medicine |
| Divisions: | Faculty of Medicine |
| Depositing User: | Ms Zaharah Ramly |
| Date Deposited: | 13 Jul 2023 04:53 |
| Last Modified: | 13 Jul 2023 04:53 |
| URI: | http://eprints.um.edu.my/id/eprint/39551 |
Actions (login required)
 |
View Item |
