Shabery, Aidawati Mohamed and Widodo, Riyanto Teguh and Chik, Zamri (2023) Formulation and in vivo pain assessment of a novel niosomal lidocaine and prilocaine in an emulsion gel (Emulgel) of semisolid palm oil base for topical drug delivery. Gels, 9 (2). ISSN 2310-2861, DOI https://doi.org/10.3390/gels9020096.
Full text not available from this repository.Abstract
This study aimed to formulate semisolid niosomal encapsulated lidocaine and prilocaine using the patented palm oil base Hamin-C-(R) for further characterization and in vivo pain assessment. Seven formulations were initially studied with various chemical compositions. A thin-layer film hydration method was used to produce niosome using a mixture of surfactant (Span((R)) 40 or Span((R)) 60) and cholesterol (CHOL) at a 1:1 ratio, with/without a charge-inducing agent (diacetyl phosphate) (DCP) and with/without labrasol((R)). Niosome F1 formulation had been identified as the highest %EE achieved, at 53.74 and 55.63% for prilocaine and lidocaine, respectively. Furthermore, NIO-HAMIN F1 emulgel indicated the best formulation with higher permeability of prilocaine and lidocaine compared to the rest of the formulations. The reformulation of optimization of NIO-HAMIN F1 emulgel using a cold process to NIO-HAMIN F1-C emulgel to improve the viscosity resulted in higher diffusion of prilocaine and lidocaine by 5.71 and 33.38%, respectively. In vivo pain perception studies by verbal rating score (VRS) and visual analogue score (VAS) on healthy subjects show a comparable local anesthetic effect between NIO-HAMIN F1-C emulgel and EMLA((R)) cream.
| Item Type: | Article |
|---|---|
| Funders: | UM-71-KWG-DM |
| Uncontrolled Keywords: | Niosome; Lidocaine; Prilocaine; Topical drug delivery; Local anesthetic; Nanoparticles |
| Subjects: | R Medicine > RM Therapeutics. Pharmacology |
| Divisions: | Faculty of Medicine Faculty of Pharmacy > Department of Pharmaceutical Technology |
| Depositing User: | Ms Zaharah Ramly |
| Date Deposited: | 01 Dec 2023 03:14 |
| Last Modified: | 01 Dec 2023 03:14 |
| URI: | http://eprints.um.edu.my/id/eprint/38735 |
Actions (login required)
 |
View Item |
