Chan, Yee Teng and Cheok, Yi Ying and Cheong, Heng Choon and Tang, Ting Fang and Sulaiman, Sofiah and Hassan, Jamiyah and Looi, Chung Yeng and Tan, Kim-Kee and Abu Bakar, Sazaly and Wong, Won Fen (2023) Immune recognition versus immune evasion systems in Zika virus infection. Biomedicines, 11 (2). ISSN 2227-9059, DOI https://doi.org/10.3390/biomedicines11020642.
Full text not available from this repository.Abstract
The reemergence of the Zika virus (ZIKV) infection in recent years has posed a serious threat to global health. Despite being asymptomatic or mildly symptomatic in a majority of infected individuals, ZIKV infection can result in severe manifestations including neurological complications in adults and congenital abnormalities in newborns. In a human host, ZIKV is primarily recognized by RIG-like receptors and Toll-like receptors that elicit anti-viral immunity through the secretion of type I interferon (IFN) to limit viral survival, replication, and pathogenesis. Intriguingly, ZIKV evades its host immune system through various immune evasion strategies, including suppressing the innate immune receptors and signaling pathways, mutation of viral structural and non-structural proteins, RNA modulation, or alteration of cellular pathways. Here, we present an overview of ZIKV recognition by the host immune system and the evasion strategies employed by ZIKV. Characterization of the host-viral interaction and viral disease mechanism provide a platform for the rational design of novel prophylactic and therapeutic strategies against ZIKV infection.
| Item Type: | Article |
|---|---|
| Funders: | Malaysian Ministry of Higher Education Long-Term Research, LRGS/MRUN/F1/01/2018, Universiti Malaya, GPF004A-2020 |
| Uncontrolled Keywords: | Immune recognition; Immune evasion; Pathogen-recognition receptors; RIG-like receptor; Type I interferon; Zika virus |
| Subjects: | Q Science > QR Microbiology |
| Divisions: | Faculty of Medicine Deputy Vice Chancellor (Research & Innovation) Office > Tropical Infectious Diseases Research and Education Centre |
| Depositing User: | Ms Zaharah Ramly |
| Date Deposited: | 14 Nov 2023 08:07 |
| Last Modified: | 14 Nov 2023 08:07 |
| URI: | http://eprints.um.edu.my/id/eprint/38682 |
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