Yap, Yi-Jing and Wong, Pooi Fong and AbuBakar, Sazaly and Sam, Sing Sin and Shunmugarajoo, Anusha and Soh, Yih-Harng and Misbah, Suzana and Rahman, Ahmad Kashfi Ab (2023) The clinical utility of CD163 in viral diseases. Clinica Chimica Acta, 541. ISSN 0009-8981, DOI https://doi.org/10.1016/j.cca.2023.117243.
Full text not available from this repository.Abstract
Macrophage activation and hypercytokinemia are notable presentations in certain viral infections leading to severe disease and poor prognosis. Viral infections can cause macrophage polarization into the pro-inflammatory M1 or anti-inflammatory M2 phenotype. Activated M1 macrophages usually restrict viral replication whereas activated M2 macrophages suppress inflammation and promote tissue repair. In response to inflammatory stimuli, macrophages polarize to the M2 phenotype expressing hemoglobin scavenger CD163 surface receptor. The CD163 receptor is shed as the soluble form, sCD163, into plasma or tissue fluids. sCD163 causes detoxification of pro-oxidative hemoglobin which produces anti-inflammatory metabolites that promote the resolution of inflammation. Hence, increased CD163 expression in tissues and elevated circulatory levels of sCD163 have been associated with acute and chronic inflammatory diseases. CD163 and other macrophage activation markers have been commonly included in the investigation of disease pathogenesis and progression. This review provides an overview of the involvement of CD163 in viral diseases. The clinical utility of CD163 in viral disease diagnosis, progression, prognosis and treatment evaluation is discussed.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Uncontrolled Keywords: | Cytokine storm; Hemophagocytic syndrome; Inflammation; Macrophage activation; Scavenger receptor; Viruses |
| Subjects: | R Medicine R Medicine > RS Pharmacy and materia medica |
| Divisions: | Faculty of Medicine Deputy Vice Chancellor (Research & Innovation) Office > Tropical Infectious Diseases Research and Education Centre |
| Depositing User: | Ms Zaharah Ramly |
| Date Deposited: | 04 Nov 2024 05:03 |
| Last Modified: | 04 Nov 2024 05:03 |
| URI: | http://eprints.um.edu.my/id/eprint/38638 |
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