Chong, Shi-En and Chang, Felicia Wen Si and Chuaha, Kee-Huat and Sthaneshwar, Pavai and Mustapha, Nik Raihan Nik and Mahadeva, Sanjiv and Chan, Wah-Kheong (2023) Validation of the Hepamet fibrosis score in a multi-ethnic Asian population. Annals of Hepatology, 28 (2). ISSN 1665-2681, DOI https://doi.org/10.1016/j.aohep.2022.100888.
Full text not available from this repository.Abstract
Introduction and Objectives: The Hepamet fibrosis score was introduced for the diagnosis of advanced liver fibrosis in patients with non-alcoholic fatty liver disease (NAFLD). To date, external validation is limited, and its utility in combination with liver stiffness measurement (LSM) has not been explored.Material and Methods: This is a cross-sectional study on NAFLD patients who had a liver biopsy and LSM on the same day. The diagnostic performance of the Hepamet fibrosis score was evaluated using the area under the receiver operating characteristic curve (AUROC).Results: The data for 196 patients were analyzed (mean age 50 +/- 11 years old, 50% men, 56.6% Malay, 27.6% Chinese, 15.8% Indian, 67.9% NASH, 15.8% advanced liver fibrosis). The AUROC of Hepamet fibrosis score for the diagnosis of advanced liver fibrosis was 0.85 (95% CI, 0.80 -0.91). Using the <0.12 and >= 0.47 cut-offs from the original study, the sensitivity, specificity, positive predictive value, negative predictive value, the proportion of indeterminate results and misclassification rate were 81.8%, 91.8%, 47.4%, 98.2%, 32.1% and 6.1%, respectively. Using LSM <10 kPa and >= 15 kPa for the diagnosis of absence and presence of advanced liver fibrosis, respectively, in patients with Hepamet fibrosis score >= 0.47 (i.e., the two-step approach) reduced indeterminate results and misclassification to 16.1% and 3.6%, respectively.Conclusions: We found the Hepamet fibrosis score to have good diagnostic accuracy in a population that was largely unrepresented in earlier work and demonstrated its utility in a two-step approach with LSM for the diagnosis of advanced liver fibrosis.(c) 2022 Fundacion Cl iota nica Medica Sur, A.C. Published by Elsevier Espafia, S.L.U. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
| Item Type: | Article |
|---|---|
| Funders: | University of Malaya Special Research Fund, BKS067‐2017 |
| Uncontrolled Keywords: | Non-alcoholic fatty liver disease; Disease; Advanced liver fibrosis; Metabolic dysfunction-associated fatty liver |
| Subjects: | R Medicine > RB Pathology |
| Divisions: | Faculty of Medicine > Medicine Department Faculty of Medicine > Pathology Department |
| Depositing User: | Ms Zaharah Ramly |
| Date Deposited: | 01 Dec 2023 04:05 |
| Last Modified: | 01 Dec 2023 04:05 |
| URI: | http://eprints.um.edu.my/id/eprint/38633 |
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