Low, Lee Shien and Wong, Jeannie Hsiu Ding and Tan, Li Kuo and Chan, Wai Yee and Jalaludin, Muhammad Yazid and Zaini, Azriyanti Anuar and Ramli, Norlisah (2023) Preliminary study of longitudinal changes in the pituitary and brain of children on growth hormone therapy. Journal of Neuroradiology, 50 (2). pp. 271-277. ISSN 01509861, DOI https://doi.org/10.1016/j.neurad.2021.11.004.
Full text not available from this repository.Abstract
Background: In subjects with isolated growth hormone deficiency (IGHD), recombinant human growth hor-mone (rhGH) is an approved method to achieve potential mid-parental height. However, data reporting rhGH treatment response in terms of brain structure volumes were scarce. We report the volumetric changes of the pituitary gland, basal ganglia, corpus callosum, thalamus, hippocampus and amygdala in these subjects post rhGH treatment. Materials and methods: This was a longitudinal study of eight IGHD subjects (2 males, 6 females) with a mean age of 11.1 +/- 0.8 years and age-matched control groups. The pituitary gland, basal ganglia and limbic struc-tures volumes were obtained using 3T MRI voxel-based morphology. The left-hand bone age was assessed using the Tanner-Whitehouse method. Follow-up imaging was performed after an average of 1.8 +/- 0.4 years on rhGH.Results: Subjects with IGHD had a smaller mean volume of the pituitary gland, right thalamus, hippocampus, and amygdala than the controls. After rhGH the
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Uncontrolled Keywords: | Isolated growth hormonedeficiency; Recombinant human growth hormone; MRI; Volume; Pituitary |
| Subjects: | R Medicine R Medicine > R Medicine (General) > Medical technology R Medicine > RJ Pediatrics |
| Divisions: | Faculty of Medicine Faculty of Medicine > Biomedical Imaging Department Faculty of Medicine > Paediatrics Department |
| Depositing User: | Ms Zaharah Ramly |
| Date Deposited: | 25 Oct 2024 08:35 |
| Last Modified: | 25 Oct 2024 08:35 |
| URI: | http://eprints.um.edu.my/id/eprint/38529 |
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