Liew, Sook Yee and Mak, Wen Qi and Thew, Hin Yee and Khaw, Kooi Yeong and Hazni, Hazrina and Litaudon, Marc and Awang, Khalijah (2023) Neuroprotective activities of new monoterpenoid indole alkaloid from nauclea officinalis. Processes, 11 (3). ISSN 2227-9717, DOI https://doi.org/10.3390/pr11030646.
Full text not available from this repository.Abstract
Phytochemical investigation on the bark of Nauclea officinalis led to the isolation of a new monoterpenoid indole alkaloid, nauclediol. The structure of the compound was identified through extensive spectroscopic analysis. Nauclediol displayed cholinesterase-inhibitory activities towards AChE and BChE with IC50 values of 15.429 and 8.756 mu M, respectively. Statistical analysis revealed that the mode of inhibition of nauclediol was non-competitive inhibitor for both AChE and BChE. Molecular docking revealed that nauclediol interacts with the choline-binding site and the catalytic triad of TcAChE and hBChE. This study also demonstrated the neuroprotective potential of nauclediol against amyloid beta-induced cytotoxicity and LPS-induced neuroinflammation activity in a dose-dependent manner.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Uncontrolled Keywords: | Nauclea officinalis; Indole alkaloids; Amyloid beta; Neuroinflammation; Cholinesterase |
| Subjects: | Q Science > Q Science (General) Q Science > QD Chemistry |
| Divisions: | Centre for Foundation Studies in Science Centre for Natural Products Research and Drug Discovery (CENAR) |
| Depositing User: | Ms Zaharah Ramly |
| Date Deposited: | 04 Nov 2024 04:24 |
| Last Modified: | 04 Nov 2024 04:24 |
| URI: | http://eprints.um.edu.my/id/eprint/38524 |
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