Nurzatil Sharleeza, Mat Jalaluddin and Asem, Maimunah and Harikrishna, Jennifer Ann and Fuaad, Abdullah Al Hadi Ahmad (2023) Recent progress on nanocarriers for Topical-Mediated RNAi Strategies for crop protection: A review. Molecules, 28 (6). ISSN 1420-3049, DOI https://doi.org/10.3390/molecules28062700.
Full text not available from this repository.Abstract
To fulfil the growing needs of the global population, sustainability in food production must be ensured. Insect pests and pathogens are primarily responsible for one-third of food losses and harmful synthetic pesticides have been applied to protect crops from these pests and other pathogens such as viruses and fungi. An alternative pathogen control mechanism that is more ``friendly'' to the environment can be developed by externally applying double-stranded RNAs (dsRNAs) to suppress gene expression. However, the use of dsRNA sprays in open fields is complicated with respect to variable efficiencies in the dsRNA delivery, and the stability of the dsRNA on and in the plants, and because the mechanisms of gene silencing may differ between plants and between different pathogen targets. Thus, nanocarrier delivery systems have been especially used with the goal of improving the efficacy of dsRNAs. Here, we highlight recent developments in nanoparticle-mediated nanocarriers to deliver dsRNA, including layered double hydroxide, carbon dots, carbon nanotubes, gold nanoparticles, chitosan nanoparticles, silica nanoparticles, liposomes, and cell-penetrating peptides, by review of the literature and patent landscape. The effects of nanoparticle size and surface modification on the dsRNA uptake efficiency in plants are also discussed. Finally, we emphasize the overall limitation of dsRNA sprays, the risks associated, and the potential safety concerns for spraying dsRNAs on crops.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Uncontrolled Keywords: | RNA interference; Non-transformative; Exogenously applied dsRNA; Biopesticide; Delivery system; Nanocarrier |
| Subjects: | Q Science > Q Science (General) Q Science > QD Chemistry Q Science > QH Natural history > QH301 Biology |
| Divisions: | Faculty of Science Faculty of Science > Institute of Biological Sciences Faculty of Science > Department of Chemistry Deputy Vice Chancellor (Research & Innovation) Office > Centre for Research in Biotechnology for Agriculture |
| Depositing User: | Ms Zaharah Ramly |
| Date Deposited: | 22 Jul 2024 04:11 |
| Last Modified: | 22 Jul 2024 04:11 |
| URI: | http://eprints.um.edu.my/id/eprint/38509 |
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