Wong, Chris H. M. and Xu, Ning and Lim, Jasmine and Feng, Kuo-kang and Chan, Wayne K. W. and Chan, Marco T. Y. and Leung, Steven Ch and Chen, Dong-ning and Lin, Yun-zhi and Chiu, Peter K. F. and Yee, Chi Hang and Teoh, Jeremy Y. C. and Huang, Chiu-yuen and Yeoh, Wei-sien and Ong, Teng-aik and Wei, Yong and Ng, Chi-fai (2023) Adverse metabolic consequences of androgen deprivation therapy (ADT) on Asian patients with prostate cancer: Primary results from the real-life experience of ADT in Asia (READT) study. Prostate, 83 (8). pp. 801-808. ISSN 0270-4137, DOI https://doi.org/10.1002/pros.24519.
Full text not available from this repository.Abstract
BackgroundAndrogen deprivation therapy (ADT) use in prostate cancer (PCa) has seen a rising trend. We investigated the relationship between ADT and adverse changes in metabolic parameters in an Asian population. MethodsThis is an international prospective multicenter single-arm cohort yielded from the real-life experience of ADT in Asia (READT) registry. Consecutive ADT-naive patients diagnosed of PCa and started on ADT were prospectively recruited from 2016 and analyzed. Baseline patient characteristics, PCa disease status, and metabolic parameters were documented. Patients were followed up at 6-month interval for up to 5 years. Metabolic parameters including body weight, lipid profiles, and glycemic profiles were recorded and analyzed. Results589 patients were eligible for analysis. ADT was associated with adverse glycemic profiles, being notable at 6 months upon ADT initiation and persisted beyond 1 year. Comparing to baseline, fasting glucose level and hemoglobin A1c level increased by 4.8% (p < 0.001) and 2.7% (p < 0.001), respectively. Triglycerides level was also elevated by 16.1% at 6th month and by 20.6% at 12th month compared to baseline (p < 0.001). Mean body weight was 1.09 kg above baseline at 18th month (p < 0.001). ConclusionADT was associated with adverse metabolic parameters in terms of glycemic profiles, lipid profiles, and body weight in the Asian population. These changes developed early in the treatment and can persist beyond the first year. Regular monitoring of the biochemical profiles during treatment is paramount in safeguarding the patients' metabolic health.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Uncontrolled Keywords: | Androgen deprivation therapy; Asian; Metabolic outcomes |
| Subjects: | R Medicine > R Medicine (General) |
| Divisions: | Faculty of Medicine > Surgery Department |
| Depositing User: | Ms Zaharah Ramly |
| Date Deposited: | 28 Jun 2023 04:25 |
| Last Modified: | 28 Jun 2023 04:25 |
| URI: | http://eprints.um.edu.my/id/eprint/38428 |
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