Lim, Wei Qing and Luk, Kie Hoon Michelle and Lee, Kah Yee and Nurul, Nasuha and Loh, Sin Jade and Yeow, Zhen Xiong and Wong, Qi Xuan and Looi, Qi Hao Daniel and Chong, Pan Pan and How, Chee Wun and Hamzah, Sharina and Foo, Jhi Biau (2023) Small extracellular vesicles' miRNAs: Biomarkers and therapeutics for neurodegenerative diseases. PHARMACEUTICS, 15 (4). ISSN 19994923, DOI https://doi.org/10.3390/pharmaceutics15041216.
Full text not available from this repository.Abstract
Neurodegenerative diseases are critical in the healthcare system as patients suffer from progressive diseases despite currently available drug management. Indeed, the growing ageing population will burden the country's healthcare system and the caretakers. Thus, there is a need for new management that could stop or reverse the progression of neurodegenerative diseases. Stem cells possess a remarkable regenerative potential that has long been investigated to resolve these issues. Some breakthroughs have been achieved thus far to replace the damaged brain cells; however, the procedure's invasiveness has prompted scientists to investigate using stem-cell small extracellular vesicles (sEVs) as a non-invasive cell-free therapy to address the limitations of cell therapy. With the advancement of technology to understand the molecular changes of neurodegenerative diseases, efforts have been made to enrich stem cells' sEVs with miRNAs to increase the therapeutic efficacy of the sEVs. In this article, the pathophysiology of various neurodegenerative diseases is highlighted. The role of miRNAs from sEVs as biomarkers and treatments is also discussed. Lastly, the applications and delivery of stem cells and their miRNA-enriched sEVs for treating neurodegenerative diseases are emphasised and reviewed.
| Item Type: | Article |
|---|---|
| Funders: | Taylor’s University |
| Uncontrolled Keywords: | Extracellular vesicles; Exosomes; miRNAs; Neurodegeneration; Stem cells |
| Subjects: | R Medicine R Medicine > RM Therapeutics. Pharmacology |
| Divisions: | Faculty of Medicine > Orthopaedic Surgery Department |
| Depositing User: | Ms Zaharah Ramly |
| Date Deposited: | 08 Nov 2024 02:56 |
| Last Modified: | 08 Nov 2024 02:56 |
| URI: | http://eprints.um.edu.my/id/eprint/38349 |
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