Obon-Santacana, Mireia and Lujan-Barroso, Leila and Freisling, Heinz and Naudin, Sabine and Boutron-Ruault, Marie-Christine and Mancini, Francesca Romana and Rebours, Vinciane and Kuehn, Tilman and Katzke, Verena and Boeing, Heiner and Tjonneland, Anne and Olsen, Anja and Overvad, Kim and Lasheras, Cristina and Rodriguez-Barranco, Miguel and Amiano, Pilar and Santiuste, Carmen and Ardanaz, Eva and Khaw, Kay-Thee and Wareham, Nicholas J. and Schmidt, Julie A. and Aune, Dagfinn and Trichopoulou, Antonia and Thriskos, Paschalis and Peppa, Eleni and Masala, Giovanna and Grioni, Sara and Tumino, Rosario and Panico, Salvatore and Bueno-de-Mesquita, Bas and Sciannameo, Veronica and Vermeulen, Roel and Sonestedt, Emily and Sund, Malin and Weiderpass, Elisabete and Skeie, Guri and Gonzalez, Carlos A. and Riboli, Elio and Duell, Eric J. (2020) Consumption of nuts and seeds and pancreatic ductal adenocarcinoma risk in the European Prospective Investigation into Cancer and Nutrition. International Journal of Cancer, 146 (1). pp. 76-84. ISSN 0020-7136, DOI https://doi.org/10.1002/ijc.32415.
Full text not available from this repository.Abstract
Four epidemiologic studies have assessed the association between nut intake and pancreatic cancer risk with contradictory results. The present study aims to investigate the relation between nut intake (including seeds) and pancreatic ductal adenocarcinoma (PDAC) risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Cox proportional hazards models were used to estimate hazards ratio (HR) and 95% confidence intervals (95% CI) for nut intake and PDAC risk. Information on intake of nuts was obtained from the EPIC country-specific dietary questionnaires. After a mean follow-up of 14 years, 476,160 participants were eligible for the present study and included 1,283 PDAC cases. No association was observed between consumption of nuts and PDAC risk (highest intake vs nonconsumers: HR, 0.89; 95% CI, 0.72-1.10; p-trend = 0.70). Furthermore, no evidence for effect-measure modification was observed when different subgroups were analyzed. Overall, in EPIC, the highest intake of nuts was not statistically significantly associated with PDAC risk.
| Item Type: | Article |
|---|---|
| Funders: | UK Research & Innovation (UKRI) Medical Research Council UK (MRC) (MC_UU_12015/1), UK Research & Innovation (UKRI) Medical Research Council UK (MRC) (MR/N003284/1) |
| Uncontrolled Keywords: | Pancreatic cancer; Nuts; Seeds; Diet; Intake; EPIC; Prospective cohort study |
| Subjects: | R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) |
| Divisions: | Faculty of Medicine |
| Depositing User: | Ms Zaharah Ramly |
| Date Deposited: | 20 May 2023 02:21 |
| Last Modified: | 20 May 2023 02:21 |
| URI: | http://eprints.um.edu.my/id/eprint/37136 |
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