Liew, Su Ki and Malagobadan, Sharan and Arshad, Norhafiza M. and Nagoor, Noor Hasima (2020) A review of the structure-activity relationship of natural and synthetic antimetastatic compounds. Biomolecules, 10 (1). ISSN 2218-273X, DOI https://doi.org/10.3390/biom10010138.
Full text not available from this repository.Abstract
There are innumerable anticancer compounds derived from either natural or synthetic origins. Many of these compounds have been further developed through structural modifications to not only inhibit cancer cell growth but also to exert an antimetastatic effect. This is achieved by attaching different substituents to generate different structure-activity relationships. This review highlights the effectiveness of different functional groups known to have antimigration and antiproliferation activities, such as fluoro, methoxy, methyl, amino, hydroxy, nitro, bromo, chloro, methylamino, ethoxy, carbonyl, iodo, and trifluoromethyl groups. Additionally, the positioning of these functional groups plays an important role in their anticancer activities, which was evident in one of our studies comparing analogues of a natural compound. Thus, this review suggests future recommendations for the design and development of improved anticancer drugs with higher efficacy.
| Item Type: | Article |
|---|---|
| Funders: | Centre for Research in Biotechnology for Agriculture (CEBAR) Grant (RU021-2019), MOHE-Top 100 (TU002E-2018) |
| Uncontrolled Keywords: | Substituent; Synthesis; Antimetastasis; Structure-activity relationships; Biotechnology |
| Subjects: | Q Science > QD Chemistry Q Science > QH Natural history > QH301 Biology |
| Divisions: | Faculty of Science > Institute of Biological Sciences Deputy Vice Chancellor (Research & Innovation) Office > Centre for Research in Biotechnology for Agriculture |
| Depositing User: | Ms Zaharah Ramly |
| Date Deposited: | 01 Jun 2023 01:55 |
| Last Modified: | 01 Jun 2023 01:55 |
| URI: | http://eprints.um.edu.my/id/eprint/37087 |
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