Fung, S.Y. and Tan, N.H. and Sim, S.M. and Marinello, E. and Guerranti, R. (2011) Mucuna pruriens Linn. seed extract pretreatment protects against cardiorespiratory and neuromuscular depressant effects of Naja sputatrix (Javan spitting cobra) venom in rats. Indian Journal of Experimental Biology, 49 (4). pp. 254-259. ISSN 0019-5189,
|
PDF
Mucuna_pruriens_seed_extract_pretreatment_protects_against_the_cardiorespiratory_and_neuromuscular_depression_effects_of_Naja_sputatrix_venom_in_rats.pdf - Published Version Download (713kB) |
Abstract
Mucuna pruriens has been used by native Nigerians as a prophylactic for snakebite. The protective effects of M. pruriens seed extract (MPE) were investigated against the pharmacological actions of N. sputatrix (Javan spitting cobra) venom in rats. The results showed that MPE-pretreatment protected against cardiorespiratory and, to a lesser extent, neuromuscular depressant effects of N. sputatrix venom. These may be explained at least in part by the neutralisation of the cobra venom toxins by anti-MPE antibodies elicited by the MPE pretreatment.
Item Type: | Article |
---|---|
Funders: | UNSPECIFIED |
Uncontrolled Keywords: | Antivenom effects Immunology Mucuna pruriens seed Naja sputatrix venom |
Subjects: | R Medicine |
Divisions: | Faculty of Medicine |
Depositing User: | Fung Shin Yee |
Date Deposited: | 27 Sep 2012 03:00 |
Last Modified: | 27 Sep 2012 03:00 |
URI: | http://eprints.um.edu.my/id/eprint/3697 |
Actions (login required)
View Item |