Sanikini, Harinakshi and Muller, David C. and Sophiea, Marisa and Rinaldi, Sabina and Agudo, Antonio and Duell, Eric J. and Weiderpass, Elisabete and Overvad, Kim and Tjonneland, Anne and Halkjaer, Jytte and Boutron-Ruault, Marie-Christine and Carbonnel, Franck and Cervenka, Iris and Boeing, Heiner and Kaaks, Rudolf and Kuehn, Tilman and Trichopoulou, Antonia and Martimianaki, Georgia and Karakatsani, Anna and Pala, Valeria and Palli, Domenico and Mattiello, Amalia and Tumino, Rosario and Sacerdote, Carlotta and Skeie, Guri and Rylander, Charlotta and Chirlaque Lopez, Maria-Dolores and Sanchez, Maria-Jose and Ardanaz, Eva and Regner, Sara and Stocks, Tanja and Bueno-de-Mesquita, Bas and Vermeulen, Roel C. H. and Aune, Dagfinn and Tong, Tammy Y. N. and Kliemann, Nathalie and Murphy, Neil and Chadeau-Hyam, Marc and Gunter, Marc J. and Cross, Amanda J. (2020) Anthropometric and reproductive factors and risk of esophageal and gastric cancer by subtype and subsite: Results from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. International Journal of Cancer, 146 (4). pp. 929-942. ISSN 0020-7136, DOI https://doi.org/10.1002/ijc.32386.
Full text not available from this repository.Abstract
Obesity has been associated with upper gastrointestinal cancers; however, there are limited prospective data on associations by subtype/subsite. Obesity can impact hormonal factors, which have been hypothesized to play a role in these cancers. We investigated anthropometric and reproductive factors in relation to esophageal and gastric cancer by subtype and subsite for 476,160 participants from the European Prospective Investigation into Cancer and Nutrition cohort. Multivariable hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox models. During a mean follow-up of 14 years, 220 esophageal adenocarcinomas (EA), 195 esophageal squamous cell carcinomas, 243 gastric cardia (GC) and 373 gastric noncardia (GNC) cancers were diagnosed. Body mass index (BMI) was associated with EA in men (BMI >= 30vs. 18.5-25 kg/m(2): HR = 1.94, 95% CI: 1.25-3.03) and women (HR = 2.66, 95% CI: 1.15-6.19); however, adjustment for waist-to-hip ratio (WHR) attenuated these associations. After mutual adjustment for BMI and HC, respectively, WHR and waist circumference (WC) were associated with EA in men (HR = 3.47, 95% CI: 1.99-6.06 for WHR >0.96vs. <0.91; HR = 2.67, 95% CI: 1.52-4.72 for WC >98vs. <90 cm) and women (HR = 4.40, 95% CI: 1.35-14.33 for WHR >0.82vs. <0.76; HR = 5.67, 95% CI: 1.76-18.26 for WC >84vs. <74 cm). WHR was also positively associated with GC in women, and WC was positively associated with GC in men. Inverse associations were observed between parity and EA (HR = 0.38, 95% CI: 0.14-0.99; >2vs. 0) and age at first pregnancy and GNC (HR = 0.54, 95% CI: 0.32-0.91; >26vs. <22 years); whereas bilateral ovariectomy was positively associated with GNC (HR = 1.87, 95% CI: 1.04-3.36). These findings support a role for hormonal pathways in upper gastrointestinal cancers.
| Item Type: | Article |
|---|---|
| Funders: | UK Research & Innovation (UKRI) MR/M012190/1, Medical Research Council UK (MRC) MR/N003284/1 |
| Uncontrolled Keywords: | obesity; reproductive; hormones; esophageal; gastric; cancer |
| Subjects: | R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) |
| Divisions: | Faculty of Medicine > Social & Preventive Medicine Universiti Malaya Medical Centre (UMMC) |
| Depositing User: | Ms Zaharah Ramly |
| Date Deposited: | 17 Jul 2024 00:26 |
| Last Modified: | 17 Jul 2024 00:26 |
| URI: | http://eprints.um.edu.my/id/eprint/36884 |
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