Al-koshab, May and Alabsi, Aied M. and Bakri, Marina Mohd and Naicker, Manimalar Selvi and Seyedan, Atefehalsadat (2020) Chemopreventive activity of Tualang honey against oral squamous cell carcinoma-in vivo. Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontics, 129 (5). pp. 484-492. ISSN 22124403, DOI https://doi.org/10.1016/j.oooo.2020.01.009.
Full text not available from this repository.Abstract
Objective. The aim of this study was to evaluate the chemopreventive activity of Malaysian jungle Tualang honey (TH) after oral carcinogenesis induced with 4-nitroquinoline 1-oxide (4 NQO). Study Design. A total of 28 male Sprague-Dawley (SD) rats were distributed into 4 groups as follows: group 1 (nontreated group); group 2 (control), which received 4 NQO during 8 weeks in drinking water only; and groups 3 and 4, which received 4 NQO for 8 weeks in drinking water and treated with TH 1000 mg/kg and 2000 mg/kg by oral gavage for 10 weeks. All rats from all experiments were sacrificed after 22 weeks, and the incidence of oral neoplasms and histopathologic changes were microscopically evaluated. Moreover, immunohistochemical expression was analyzed in tongue specimens by using image analysis software. The expression of particular genes associated with oral cancer were assessed by using RT2 Profiler PCR Array (Qiagen, Germantown, MD). Results. TH significantly reduced the incidence of oral squamous cell carcinoma (OSCC) and suppressed cancer cell proliferation via diminishing the expression of CCND1, EGFR, and COX-2. Furthermore, TH preserved cellular adhesion (epithelial polarity) through overexpression of beta-catenin and e-cadherin and inhibited the OSCC aggressiveness by downregulating TWIST1 and RAC1. Conclusions. Our data suggest that TH exerts chemopreventive activity in an animal model in which oral cancer was induced by using 4 NQO.
| Item Type: | Article |
|---|---|
| Funders: | Ministry of Higher Education, Malaysia [Grant No: PG 253-2015 B], Universiti Malaya [Grant No: Fp 030-2015 A] |
| Uncontrolled Keywords: | Animals; Carcinoma, Squamous Cell; Honey; Male; Mouth Neoplasms; Rats; Rats, Sprague-Dawley; Tongue Neoplasms |
| Subjects: | R Medicine > RD Surgery R Medicine > RK Dentistry |
| Divisions: | Faculty of Dentistry Faculty of Medicine |
| Depositing User: | Ms Zaharah Ramly |
| Date Deposited: | 04 Nov 2024 08:13 |
| Last Modified: | 04 Nov 2024 08:13 |
| URI: | http://eprints.um.edu.my/id/eprint/36707 |
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