Loganadan, Navin Kumar and Huri, Hasniza Zaman and Vethakkan, Shireene Ratna and Hussein, Zanariah (2020) Clinical and genetic predictors of secondary sulfonylurea failure in Type 2 diabetes patients: the SUCLINGEN study. Pharmacogenomics, 21 (9). pp. 587-600. ISSN 1462-2416, DOI https://doi.org/10.2217/pgs-2019-0171.
Full text not available from this repository.Abstract
Background: Due to several limitations in the study designs of sulfonylurea pharmacogenomics studies, we investigated the clinical and genetic predictors of secondary sulfonylurea failure in Type 2 diabetes patients. Materials & methods: Patients receiving the maximum sulfonylurea and metformin doses for >1 year were enrolled. Secondary sulfonylurea failure was defined as HbA1c >7.0% (>53 mmol/mol) after a 12-month follow-up. Results: By multivariate analysis, increased insulin resistance (HOMA2-IR), baseline HbA1c >7.0%, residing in eastern Peninsular Malaysia, and the CC genotype of rs757110 ABCC8 gene polymorphism were independent predictors of secondary sulfonylurea failure (p < 0.05) while sulfonylurea-induced hypoglycemia was protective against such failure (p < 0.05). Conclusion: Sulfonylurea does not benefit patients with an increased risk of secondary sulfonylurea failure.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Uncontrolled Keywords: | ABCC8 gene polymorphism; Insulin resistance; Risk predictors; Secondary failure; sulfonylurea |
| Subjects: | R Medicine > R Medicine (General) R Medicine > RC Internal medicine |
| Divisions: | Faculty of Pharmacy Faculty of Pharmacy > Department of Clinical Pharmacy and Pharmacy Practice |
| Depositing User: | Ms Zaharah Ramly |
| Date Deposited: | 01 Dec 2023 02:09 |
| Last Modified: | 01 Dec 2023 02:09 |
| URI: | http://eprints.um.edu.my/id/eprint/36660 |
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