Paraoxonase 1 activity as a predictor of cardiovascular disease in type 2 diabetes

Poh, R. and Muniandy, S. (2010) Paraoxonase 1 activity as a predictor of cardiovascular disease in type 2 diabetes. Southeast Asian Journal of Tropical Medicine and Public Health, 41 (5). pp. 1231-1246. ISSN 0038-3619,

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Abstract

The role of paraoxonase 1 in cardiovascular disease complications in type 2 diabetes mellitus is not fully understood. We studied paraoxonase activity towards paraoxon in 188 non-diabetic and 140 diabetic subjects using general linear models and univariate analysis. Adjusting for age revealed a reduction in activity towards paraoxon was associated with a significant increase in risk (p=0.023) for cardiovascular disease complications in diabetic patients. Multivariate analysis of two plasma measures of paraoxonase activity using paraoxon and diazoxon also showed reduced paraoxonase activity towards paraoxon was associated with a significant increase in risk (p=0.045) for cardiovascular disease complications in diabetic patients. These analyses showed that a reduced paraoxonase activity towards paraoxon was associated with ethnicity. Based on multivariate analysis, subjects of Malay ethnic origin have significantly higher than expected activity (p=0.008, compared to Indians), towards paraoxon than subjects of Chinese origin who in turn had higher than expected paraoxonase activity (p=0.028, compared to Indians) Indian subjects.

Item Type:	Article
Funders:	UNSPECIFIED
Additional Information:	Correspondence: Rozaida Poh Yuen Ying, Department of Molecular Medicine, Faculty of Medicine, University of Malaya 50603, Kuala Lumpur, Malaysia. Tel: +603-79676611; Fax: +603-79676600 E-mail: rozaiday@um.edu.my
Uncontrolled Keywords:	paraoxonase 1, cardiovascular disease, type 2 diabetes
Subjects:	R Medicine
Divisions:	Faculty of Medicine
Depositing User:	Ms Haslinda Lahuddin
Date Deposited:	12 Sep 2012 03:19
Last Modified:	19 Oct 2018 08:28
URI:	http://eprints.um.edu.my/id/eprint/3662

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