Butt, Julia and Jenab, Mazda and Pawlita, Michael and Tjonneland, Anne and Kyro, Cecilie and Boutron-Ruault, Marie-Christine and Carbonnel, Franck and Dong, Catherine and Kaaks, Rudolf and Kuhn, Tilman and Boeing, Heiner and Schulze, Matthias B. and Trichopoulou, Antonia and Karakatsani, Anna and La Vecchia, Carlo and Palli, Domenico and Agnoli, Claudia and Tumino, Rosario and Sacerdote, Carlotta and Panico, Salvatore and Bueno-de-Mesquita, Bas and Vermeulen, Roel and Gram, Inger T. and Weiderpass, Elisabete and Borch, Kristin Benjaminsen and Quiros, Jose Ramon and Agudo, Antonio and Rodriguez-Barranco, Miguel and Santiuste, Carmen and Ardanaz, Eva and Van Guelpen, Bethany and Harlid, Sophia and Imaz, Liher and Perez-Cornago, Aurora and Gunter, Marc J. and Zouiouich, Semi and Park, Jin Young and Riboli, Elio and Cross, Amanda J. and Heath, Alicia K. and Waterboer, Tim and Hughes, David J. (2020) Antibody responses to Helicobacter pylori and risk of developing colorectal cancer in a European cohort. Cancer Epidemiology Biomarkers & Prevention, 29 (7). pp. 1475-1481. ISSN 1055-9965, DOI https://doi.org/10.1158/1055-9965.EPI-19-1545.
Full text not available from this repository.Abstract
Background: While Helicobacter pylori (H. pylori) is the major cause of gastric cancer, it has also been suggested to be involved in colorectal cancer development. However, prospective studies addressing H. pylori and colorectal cancer are sparse and inconclusive. We assessed the association of antibody responses to H. pylori proteins with colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Methods: We applied H. pylori multiplex serology to measure antibody responses to 13 H. pylori proteins in prediagnostic serum samples from 485 colorectal cancer cases and 485 matched controls nested within the EPIC study. Odds ratios (OR) and 95% confidence intervals (CI) were calculated using multivariable conditional logistic regression to estimate the association of H. pylori overall and protein-specific seropositivity with odds of developing colorectal cancer. Results: Fifty-one percent of colorectal cancer cases were H. pylori seropositive compared with 44% of controls, resulting in an OR of 1.36 (95% CI, 1.00-1.85). Among the 13 individual H. pylori proteins, the association was driven mostly by seropositivity to Helicobacter cysteine-rich protein C (HcpC; OR: 1.66; 95% CI, 1.19-2.30) and Vacuolating cytotoxin A (VacA) (OR: 1.34; 95% CI, 0.99-1.82), the latter being nonstatistically significant only in the fully adjusted model. Conclusions: In this prospective multicenter European study, antibody responses to H. pylori proteins, specifically HcpC and VacA, were associated with an increased risk of developing colorectal cancer. Impact: Biological mechanisms for a potential causal role of H. pylori in colorectal carcinogenesis need to be elucidated, and subsequently whether H. pylori eradication may decrease colorectal cancer incidence.
| Item Type: | Article |
|---|---|
| Funders: | Health Research Board - Ireland HRB-ILP-021 |
| Uncontrolled Keywords: | Atrophic gastritis; infection; association |
| Subjects: | R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) |
| Divisions: | Faculty of Medicine > Social & Preventive Medicine |
| Depositing User: | Ms Zaharah Ramly |
| Date Deposited: | 17 Jul 2024 03:32 |
| Last Modified: | 17 Jul 2024 03:32 |
| URI: | http://eprints.um.edu.my/id/eprint/36564 |
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