Ho, Weang-Kee and Tan, Min-Min and Mavaddat, Nasim and Tai, Mei-Chee and Mariapun, Shivaani and Li, Jingmei and Ho, Peh-Joo and Dennis, Joe and Tyrer, Jonathan P. and Bolla, Manjeet K. and Michailidou, Kyriaki and Wang, Qin and Kang, Daehee and Choi, Ji-Yeob and Jamaris, Suniza and Shu, Xiao-Ou and Yoon, Sook-Yee and Park, Sue K. and Kim, Sung-Won and Shen, Chen-Yang and Yu, Jyh-Cherng and Tan, Ern Yu and Chan, Patrick Mun Yew and Muir, Kenneth and Lophatananon, Artitaya and Wu, Anna H. and Stram, Daniel O. and Matsuo, Keitaro and Ito, Hidemi and Chan, Ching Wan and Ngeow, Joanne and Yong, Wei Sean and Lim, Swee Ho and Lim, Geok Hoon and Kwong, Ava and Chan, Tsun L. and Tan, Su Ming and Seah, Jaime and John, Esther M. and Kurian, Allison W. and Koh, Woon-Puay and Khor, Chiea Chuen and Iwasaki, Motoki and Yamaji, Taiki and Tan, Kiak Mien Veronique and Tan, Kiat Tee Benita and Spinelli, John J. and Aronson, Kristan J. and Hasan, Siti Norhidayu and Rahmat, Kartini and Vijayananthan, Anushya and Sim, Xueling and Pharoah, Paul D. P. and Zheng, Wei and Dunning, Alison M. and Simard, Jacques and van Dam, Rob Martinus and Yip, Cheng-Har and Taib, Nur Aishah Mohd and Hartman, Mikael and Easton, Douglas F. and Teo, Soo-Hwang and Antoniou, Antonis C. (2020) European polygenic risk score for prediction of breast cancer shows similar performance in Asian women. Nature Communications, 11 (1). ISSN 20411723, DOI https://doi.org/10.1038/s41467-020-17680-w.
Full text not available from this repository.Abstract
Polygenic risk scores (PRS) have been shown to predict breast cancer risk in European women, but their utility in Asian women is unclear. Here we evaluate the best performing PRSs for European-ancestry women using data from 17,262 breast cancer cases and 17,695 controls of Asian ancestry from 13 case-control studies, and 10,255 Chinese women from a prospective cohort (413 incident breast cancers). Compared to women in the middle quintile of the risk distribution, women in the highest 1% of PRS distribution have a similar to 2.7-fold risk and women in the lowest 1% of PRS distribution has similar to 0.4-fold risk of developing breast cancer. There is no evidence of heterogeneity in PRS performance in Chinese, Malay and Indian women. A PRS developed for European-ancestry women is also predictive of breast cancer risk in Asian women and can help in developing risk-stratified screening programmes in Asia.
| Item Type: | Article |
|---|---|
| Funders: | Fondation CHU de Québec, Government of Canada, National University of Singapore, National Medical Research Council, Malaysian Ministry of Science, National Research Foundation of Korea [Grant No: C12292/ A20861, NRF-NRFF2017-02], Malaysian Ministry of Higher Education High Impact Research [Grant No: UM.C/HIR/MOHE/06] |
| Uncontrolled Keywords: | Adult; Aged; Asia; Breast Neoplasms; Case-Control Studies; Europe; Female; Genetic Predisposition to Disease; Genome-Wide Association Study; Humans; Middle Aged; Multifactorial Inheritance; Odds Ratio; Polymorphism, Single Nucleotide; Prognosis; Risk |
| Subjects: | R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) |
| Divisions: | Faculty of Medicine > Biomedical Imaging Department |
| Depositing User: | Ms Zaharah Ramly |
| Date Deposited: | 28 Oct 2024 13:37 |
| Last Modified: | 28 Oct 2024 13:37 |
| URI: | http://eprints.um.edu.my/id/eprint/36531 |
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