Low, Joyce Siew Yong and Thevarajah, T. Malathi and Chang, Siow Wee and Goh, Boon Tong and Khor, Sook Mei (2020) Biosensing based on surface-enhanced Raman spectroscopy as an emerging/next-generation point-of-care approach for acute myocardial infarction diagnosis. Critical Reviews in Biotechnology, 40 (8). pp. 1191-1209. ISSN 07388551, DOI https://doi.org/10.1080/07388551.2020.1808582.
Full text not available from this repository.Abstract
Cardiovascular disease is a major global health issue. In particular, acute myocardial infarction (AMI) requires urgent attention and early diagnosis. The use of point-of-care diagnostics has resulted in the improved management of cardiovascular disease, but a major drawback is that the performance of POC devices does not rival that of central laboratory tests. Recently, many studies and advances have been made in the field of surface-enhanced Raman scattering (SERS), including the development of POC biosensors that utilize this detection method. Here, we present a review of the strengths and limitations of these emerging SERS-based biosensors for AMI diagnosis. The ability of SERS to multiplex sensing against existing POC detection methods are compared and discussed. Furthermore, SERS calibration-free methods that have recently been explored to minimize the inconvenience and eliminate the limitations caused by the limited linear range and interassay differences found in the calibration curves are outlined. In addition, the incorporation of artificial intelligence (AI) in SERS techniques to promote multivariate analysis and enhance diagnostic accuracy are discussed. The future prospects for SERS-based POC devices that include wearable POC SERS devices toward predictive, personalized medicine following the Fourth Industrial Revolution are proposed.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Uncontrolled Keywords: | SERS; Calibration-free; Point-of-care; Acute myocardial infarction; Artificial intelligence; Precision medicine |
| Subjects: | Q Science > Q Science (General) Q Science > QD Chemistry Q Science > QH Natural history > QH301 Biology R Medicine R Medicine > RB Pathology |
| Divisions: | Faculty of Medicine Faculty of Medicine > Pathology Department Faculty of Science Faculty of Science > Institute of Biological Sciences Faculty of Science > Department of Chemistry |
| Depositing User: | Ms Zaharah Ramly |
| Date Deposited: | 30 Nov 2023 10:40 |
| Last Modified: | 30 Nov 2023 10:40 |
| URI: | http://eprints.um.edu.my/id/eprint/36483 |
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