Sheam, Md Moinuddin and Bin Syed, Shifath and Nain, Zulkar and Tang, Swee-Seong and Paul, Dipak Kumar and Ahmed, Kazi Rejvee and Biswas, Sudhangshu Kumar (2020) Community-acquired pneumonia: Aetiology, antibiotic resistance and prospects of phage therapy. Journal of CHEMOTHERAPY, 32 (8). pp. 395-410. ISSN 1120-009X, DOI https://doi.org/10.1080/1120009X.2020.1807231.
Full text not available from this repository.Abstract
Bacteria are the most common aetiological agents of community-acquired pneumonia (CAP) and use a variety of mechanisms to evade the host immune system. With the emerging antibiotic resistance, CAP-causing bacteria have now become resistant to most antibiotics. Consequently, significant morbimortality is attributed to CAP despite their varying rates depending on the clinical setting in which the patients being treated. Therefore, there is a pressing need for a safe and effective alternative or supplement to conventional antibiotics. Bacteriophages could be a ray of hope as they are specific in killing their host bacteria. Several bacteriophages had been identified that can efficiently parasitize bacteria related to CAP infection and have shown a promising protective effect. Thus, bacteriophages have shown immense possibilities against CAP inflicted by multidrug-resistant bacteria. This review provides an overview of common antibiotic-resistant CAP bacteria with a comprehensive summarization of the promising bacteriophage candidates for prospective phage therapy.
| Item Type: | Article |
|---|---|
| Funders: | None |
| Uncontrolled Keywords: | Community-acquired pneumonia; Aetiology; Antibiotic resistance; Bacteriophage; Lefamulin; Phage therapy |
| Subjects: | R Medicine > RB Pathology R Medicine > RM Therapeutics. Pharmacology |
| Divisions: | Faculty of Science |
| Depositing User: | Ms Zaharah Ramly |
| Date Deposited: | 28 Nov 2023 01:10 |
| Last Modified: | 03 Dec 2023 01:41 |
| URI: | http://eprints.um.edu.my/id/eprint/36482 |
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