Salleh, Noor Hafizan Mat and Rahman, Mohd Faizal Abdul and Samsusah, Samsiah and De Silva, Jeremy Ryan and Ng, David Chun-Ern and Ghozali, Azilawati Hanim and Tan, Jia Hui and Lai, Meng Yee and Amir, Amirah and Liew, Jonathan Wee Kent and Lau, Yee Ling (2020) Case report: recurrence of Plasmodium vivax malaria due to defective cytochrome P450 2D6 function in Pos Lenjang, Pahang, Malaysia. Transactions of the Royal Society of Tropical Medicine and Hygiene, 114 (9). pp. 700-703. ISSN 0035-9203, DOI https://doi.org/10.1093/trstmh/traa042.
Full text not available from this repository.Abstract
Five children in Pos Lenjang, Pahang, Malaysia were PCR-positive for vivax malaria and were admitted to the hospital from 5 to 26 July 2019. One of the patients experienced three episodes of recurrence of vivax malaria. Microsatellite analysis showed that reinfection is unlikely. Drug resistance analysis indicated that Riamet (artemether-lumefantrine) is effective. Cytochrome P450 2D6 (CYP2D6) testing showed that this patient has defective CYP2D6 function. Primaquine failure to clear the Plasmodium vivax hypnozoites may be the cause of recurring infections in this patient. This report highlights the need for the development of Liver-stage curative antimalarials that do not require metabolism by the CYP2D6 enzyme.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Uncontrolled Keywords: | CYP2D6; Drug resistance; Mutation; Plasmodium vivax; Recurrent |
| Subjects: | R Medicine S Agriculture > SF Animal culture |
| Divisions: | Faculty of Medicine Faculty of Medicine > Parasitology Deparment |
| Depositing User: | Ms Zaharah Ramly |
| Date Deposited: | 30 Nov 2023 07:38 |
| Last Modified: | 30 Nov 2023 07:38 |
| URI: | http://eprints.um.edu.my/id/eprint/36459 |
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