Choo, Siew Woh and Zhou, Jinfeng and Tian, Xuechen and Zhang, Siyuan and Qiang, Shen and O'Brien, Stephen J. and Tan, Ka Yun and Platto, Sara and Koepfli, Klaus-Peter and Antunes, Agostinho and Sitam, Frankie Thomas (2020) Are pangolins scapegoats of the COVID-19 outbreak-CoV transmission and pathology evidence? Conservation Letters, 13 (6). DOI https://doi.org/10.1111/conl.12754.
Full text not available from this repository.Abstract
The COVID-19 outbreak has infected over 6 million people across the world. The origin of COVID-19 coronavirus (CoV) remains unknown, although pangolins have been suggested as potential hosts. We investigated two pangolins seized in Guangdong Province, China. Molecular screening revealed CoV in one pangolin (''Dahu''), while another (''Meidong'') was infected byEhrlichia ruminantium. Dahu exhibited difficulty breathing, infections of lung, intestines, and nostrils, as revealed by computed tomography imaging and necropsy. Previous phylogenetic analyses showed bat coronavirus RaTG13 is closer to COVID-19 CoV compared to pangolin coronavirus. Over 20 caregivers have had close physical contact with CoV-positive Dahu, but none became infected with CoV. Our data suggest that pangolins are unlikely the natural reservoir or secondary hosts of COVID-19 CoV. Pangolins seems to be victims infected by CoV carried by a not yet unidentified natural reservoir host species, perhaps due to their weakened immune system.
| Item Type: | Article |
|---|---|
| Funders: | Wenzhou-Kean University [Grant No: 5000105] |
| Uncontrolled Keywords: | Animal conservation; Coronavirus; COVID-19; CT imaging; Pangolins; Pangolin pathology |
| Subjects: | Q Science > Q Science (General) Q Science > QH Natural history > QH301 Biology |
| Divisions: | Faculty of Science > Institute of Biological Sciences |
| Depositing User: | Ms Zaharah Ramly |
| Date Deposited: | 27 Nov 2024 04:03 |
| Last Modified: | 28 Nov 2024 04:11 |
| URI: | http://eprints.um.edu.my/id/eprint/36412 |
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