Khandaker, Mayeen Uddin and Nagatsu, Kotaro and Minegishi, Katsuyuki and Zhang, Ming-Rong and Jalilian, Amir R. and Bradley, D.A. (2020) Cyclotron production of no carrier added Re-186g radionuclide for theranostic applications. Applied Radiation and Isotopes, 166. ISSN 0969-8043, DOI https://doi.org/10.1016/j.apradiso.2020.109428.
Full text not available from this repository.Abstract
Re-186g (T-1/2 = 3.7183 d, E-(beta)mean(-)= 346.7 keV, I-(beta)mean(-) = 92.59%), a mixed beta and gamma-emitter shows great potential for use in theranostic applications. The dominant Re-185(n,gamma) route, via use of a nuclear reactor, provides 1(86g)Re in carrier added form with low specific activity, while cyclotrons offer no carrier-added (NCA) high specific activity production of 186 gRe. However, to be able to select the best possible nuclear reaction and to optimize the production route via the use of a cyclotron, information on the excitation function for the reaction of interest as well as for the competing reactions is necessary. Accordingly, we have conducted a detailed study of the excitation functions for W-nat(d, x) reactions in seeking optimized parameters for the NCA production of 186 gRe. Noting a discrepancy among the experimental data, we made an evaluation of the available literature, finally selecting optimum parameters for the production of Re-186g via the W-186(d,2n) Re-186 reaction. These beam parameters were then used for batch production of Re-186g by irradiating an enriched W-186 metallic powder target, followed by a subsequent automated chemical separation process. The preliminary results show 98.1% radionuclidic purity of Re-186g at 8 h subsequent to the End of Bombardment (EOB), offering the potential for use in clinical applications.
| Item Type: | Article |
|---|---|
| Funders: | International Atomic Energy Agency (Grant No. 20566), Sunway University (Grant No. GRTIN-RSF-SHMS-CBP-03-2020) |
| Uncontrolled Keywords: | Deuteron cyclotron; Enriched W-186 powder; Theranostic Re-186g; Excitation function; Chemical separation; NCA production; High radionuclidic purity product |
| Subjects: | Q Science > QC Physics |
| Divisions: | Faculty of Science > Department of Physics |
| Depositing User: | Ms Zaharah Ramly |
| Date Deposited: | 28 Dec 2023 07:31 |
| Last Modified: | 17 Sep 2024 07:16 |
| URI: | http://eprints.um.edu.my/id/eprint/36219 |
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