Ngoi, Soo Tein and Muhamad, Anis Najwa and Teh, Cindy Shuan Ju and Chong, Chun Wie and Abdul Jabar, Kartini and Chai, Lay Ching and Leong, Kin Chong and Tee, Loong Hua and AbuBakar, Sazaly (2021) βeta-lactam resistance in upper respiratory tract pathogens isolated from a tertiary hospital in Malaysia. Pathogens, 10 (12). ISSN 2076-0817, DOI https://doi.org/10.3390/pathogens10121602.
Full text not available from this repository.Abstract
The rise of antimicrobial resistance (AMR) among clinically important bacteria, including respiratory pathogens, is a growing concern for public health worldwide. Common causative bacteria for upper respiratory tract infections (URTIs) include Streptococcus pneumoniae and Haemophilus influenzae, and sometimes Staphylococcus aureus. We assessed the β-lactam resistant trends and mechanisms of 150 URTI strains isolated in a tertiary care hospital in Kuala Lumpur Malaysia. High rates of non-susceptibility to penicillin G (38), amoxicillin-clavulanate (48), imipenem (60), and meropenem (56) were observed in S. pneumoniae. Frequent mutations at STMK and SRNVP motifs in PBP1a (41), SSNT motif in PBP2b (32), and STMK and LKSG motifs in PBP2x (41) were observed in S. pneumoniae. H. influenzae remained highly susceptible to most β-lactams, except for ampicillin. Approximately half of the ampicillin non-susceptible H. influenzae harboured PBP3 mutations (56) and only blaTEM was detected in the ampicillin-resistant strains (47). Methicillin-susceptible S. aureus (MSSA) strains were mostly resistant to penicillin G (92), with at least two-fold higher median minimum inhibitory concentrations (MIC) for all penicillin antibiotics (except ticarcillin) compared to S. pneumoniae and H. influenzae. Almost all URTI strains (88–100) were susceptible to cefcapene and flomoxef. Overall, β-lactam antibiotics except penicillins remained largely effective against URTI pathogens in this region. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
| Item Type: | Article |
|---|---|
| Funders: | Universiti Malaya Research Fund[RU005-2020], Shionogi Singapore Pte. Ltd. |
| Uncontrolled Keywords: | Antimicrobial resistance;Beta-lactamase;Haemophilus influenzae;Penicillin resistance;Penicillin-binding proteins;Staphylococcus aureus;Streptococcus pneumoniae |
| Subjects: | Q Science > QR Microbiology |
| Divisions: | Faculty of Medicine |
| Depositing User: | Ms Zaharah Ramly |
| Date Deposited: | 31 Oct 2022 07:22 |
| Last Modified: | 31 Oct 2022 07:22 |
| URI: | http://eprints.um.edu.my/id/eprint/36023 |
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