Sakharkar, M.K. and Rajamanickam, K. and Ji, S. and Dhillon, S.K. and Yang, J. (2021) Pairwise correlation of genes involved in glucose metabolism: A potential diagnostic marker of cancer? Genes and Cancer, 12. pp. 69-76. ISSN 19476019, DOI https://doi.org/10.18632/GENESANDCANCER.216.
Full text not available from this repository.Abstract
Cancer is a highly malignant disease, killing approximately 10 million people worldwide in 2020. Cancer patient survival substantially relies on early diagnosis. In this study, we evaluated whether genes involved in glucose metabolism could be used as potential diagnostic markers for cancer. In total, 127 genes were examined for their gene expression levels and pairwise gene correlations. Genes ADH1B and PDHA2 were differentially expressed in most of the 12 types of cancer and five pairs of genes exhibited consistent correlation changes (from strong correlations in normal controls to weak correlations in cancer patients) across all types of cancer. Thus, the two differentially expressed genes and five gene pairs could be potential diagnostic markers for cancer. Further preclinical and clinical studies are warranted to prove whether these genes and/or gene pairs would indeed aid in early diagnosis of cancer. © 2021 Sakharkar et al.
| Item Type: | Article |
|---|---|
| Funders: | University of Saskatchewan, Natural Sciences and Engineering Research Council of Canada (Grant No. 419247) |
| Uncontrolled Keywords: | Diagnostic marker; Gene expression; Gene pair correlation; Pan-cancer analysis; Protein-protein interaction network |
| Subjects: | Q Science > Q Science (General) |
| Divisions: | Faculty of Science > Institute of Biological Sciences |
| Depositing User: | Ms Zaharah Ramly |
| Date Deposited: | 20 Dec 2023 12:06 |
| Last Modified: | 20 Dec 2023 12:06 |
| URI: | http://eprints.um.edu.my/id/eprint/35889 |
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