Pseudomonas aeruginosa: epidemiology of bacteremia and antimicrobial susceptibility pattern in a teaching hospital in Kuala Lumpur

Nadeem, S.R. and Karunakaran, Rina and Hassan, Hamimah and Puthucheary, Savithri Devi (2006) Pseudomonas aeruginosa: epidemiology of bacteremia and antimicrobial susceptibility pattern in a teaching hospital in Kuala Lumpur. Journal of the University of Malaya Medical Centre (JUMMEC), 9 (1). 14 -19. ISSN 1823-7339,

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Abstract

A cross-sectional study of 109 patients with Pseudomonas aeruginosa bacteremia from the University of Malaya Medical Centre (UMMC) in the years 2000 and 2001 was conducted to describe epidemiological features, underlying diseases, possible source of infection, early mortality among patients as well as the antibiotic susceptibility pattern of patients' isolates. Further analysis of the 87 patient records that were available revealed that the mean age was 48.5 years (SD ' 25.1). Fifty-two per cent of cases were male and 48% female. Seventy-nine per cent of infections were nosocomially acquired, 33% of bacteremias were polymicrobial, 47% of patients had a continuous bladder drainage catheter (CBD) in situ, 33% had a central venous catheter (CVL) present at the time of bacteremia and 30% were ventilated. Sixty-eight per cent of patients had an underlying immunosuppressed state and 26% had undergone surgery involving general anesthesia in the week prior to isolating P. aeruginosa. Among the 23 patients with early mortality, 61% were on inappropriate antimicrobials. Most of the patients' isolates were sensitive to imipenem (86%), ciprofloxacin (81%), ceftazidime (79%), gentamicin (78%) and cefoperazone (77%). Among the community acquired strains, however, there was 100% sensitivity to imipenem, ceftazidime, cefoperazone and ciprofloxacin.

Item Type:	Article
Funders:	UNSPECIFIED
Additional Information:	Correspondence: Dr Rina Karunakaran Department of Medical Microbiology University of Malaya Medical Centre 59100 Kuala Lumpur, Malaysia Tel: 603-7949 2774 Fax: 603-7958 4844 Email: rinakarunakaran@yahoo.com
Uncontrolled Keywords:	Pseudomonas aeruginosa; bacteremia; antimicrobial susceptibility
Subjects:	R Medicine
Divisions:	Faculty of Medicine
Depositing User:	hamimah hamimah hassan
Date Deposited:	06 Aug 2012 01:52
Last Modified:	06 Aug 2020 07:26
URI:	http://eprints.um.edu.my/id/eprint/3557

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