Al-Japairai, K.A.S. and Chatterjee, B. and Mahmood, Syed and Almurisi, S.H. (2021) A bioanalytical method for quantification of telmisartan in rat plasma; development, validation and application to pharmacokinetic study. Research Journal of Pharmacy and Technology, 14 (4). pp. 2139-2144. ISSN 0974-3618, DOI https://doi.org/10.52711/0974-360X.2021.00379.
Full text not available from this repository.Abstract
The telmisartan was determined in a rat plasma using developed and validated a reversed-phase high performance liquid chromatographic (HPLC). The pre-treatment of the plasma sample involving liquid-liquid extraction using ethanol as the extracting solvent. The HPLC method validation has been shown a linear calibration curve over a plasma concentrations range of 0.7 to 10µg/mL with a correlation coefficient of 0.9979, the limit of detection and the limit of quantification were determined to be 0.025µg/ml and 0.07µg/ml, respectively. The precision and accuracy were in an acceptable limit. The pharmacokinetic parameters of telmisartan were adequately evaluated following a single oral dose (4mg/kg) in Sprague-Dawley rats. The results observed conclude that the developed bioanalytical HPLC method is appropriate and applicable as an analytical tool in the pharmacokinetic study of telmisartan. © RJPT All right reserved.
| Item Type: | Article |
|---|---|
| Funders: | Ministry of Higher Education, Malaysia [Grant No. FRGS-17-006-572] |
| Uncontrolled Keywords: | Bioanalytical method; HPLC; Rat plasma; Telmisartan; Validation |
| Subjects: | R Medicine > RS Pharmacy and materia medica |
| Divisions: | Faculty of Pharmacy > Department of Pharmaceutical Technology |
| Depositing User: | Ms Zaharah Ramly |
| Date Deposited: | 09 Oct 2023 08:05 |
| Last Modified: | 09 Oct 2023 08:05 |
| URI: | http://eprints.um.edu.my/id/eprint/35473 |
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