Mattick, John and Libro, Silvia and Bromley, Robin and Chaicumpa, Wanpen and Chung, Matthew and Cook, Darren and Khan, Mohammad Behram and Kumar, Nikhil and Lau, Yee-Ling and Misra-Bhattacharya, Shailja and Rao, Ramakrishna and Sadzewicz, Lisa and Saeung, Atiporn and Shahab, Mohd and Sparklin, Benjamin C. and Steven, Andrew and Turner, Joseph D. and Tallon, Luke J. and Taylor, Mark J. and Moorhead, Andrew R. and Michalski, Michelle and Foster, Jeremy M. and Hotopp, Julie C. Dunning (2021) X-treme loss of sequence diversity linked to neo-X chromosomes in filarial nematodes. PLoS Neglected Tropical Diseases, 15 (10). ISSN 1935-2735, DOI https://doi.org/10.1371/journal.pntd.0009838.
Full text not available from this repository.Abstract
The sequence diversity of natural and laboratory populations of Brugia pahangi and Brugia malayi was assessed with Illumina resequencing followed by mapping in order to identify single nucleotide variants and insertions/deletions. In natural and laboratory Brugia populations, there is a lack of sequence diversity on chromosome X relative to the autosomes (pi(X)/pi(A) = 0.2), which is lower than the expected (pi(X)/pi(A) = 0.75). A reduction in diversity is also observed in other filarial nematodes with neo-X chromosome fusions in the genera Onchocerca and Wuchereria, but not those without neo-X chromosome fusions in the genera Loa and Dirofilaria. In the species with neo-X chromosome fusions, chromosome X is abnormally large, containing a third of the genetic material such that a sizable portion of the genome is lacking sequence diversity. Such profound differences in genetic diversity can be consequential, having been associated with drug resistance and adaptability, with the potential to affect filarial eradication.
| Item Type: | Article |
|---|---|
| Funders: | United States Department of Health & Human Services National Institutes of Health (NIH) - USA NIH National Institute of Allergy & Infectious Diseases (NIAID)[U19AI110820], Council of Scientific & Industrial Research (CSIR) - India[SIP0026], Faculty of Medicine[PAR-2563-07268], Office of Research Administration, Chiang Mai University, Thailand, Barnes-Jewish Hospital Foundation |
| Uncontrolled Keywords: | Recent population bottleneck;Brugia-pahangi;Draft genome;Evolution;Parasite;Malayi;Alignment;Genetics;Drug |
| Subjects: | Q Science > QR Microbiology R Medicine R Medicine > R Medicine (General) |
| Divisions: | Faculty of Medicine |
| Depositing User: | Ms Zaharah Ramly |
| Date Deposited: | 27 Oct 2022 03:14 |
| Last Modified: | 27 Oct 2022 03:14 |
| URI: | http://eprints.um.edu.my/id/eprint/35341 |
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