Govindaraj, Padmanabha Kumar and Kallarakkal, Thomas George and Zain, Rosnah Mohd and Tilakaratne, Wanninayake Mudiyanselage and Lew, Huai Lin (2021) Expression of Ki-67, Cornulin and ISG15 in non-involved mucosal surgical margins as predictive markers for relapse in oral squamous cell carcinoma (OSCC). PLoS ONE, 16 (12). ISSN 1932-6203, DOI https://doi.org/10.1371/journal.pone.0261575.
Full text not available from this repository.Abstract
Local relapse of oral squamous cell carcinoma in non-involved mucosal surgical margins indicated possibility of field alteration in the margins, which could be predicted with certain biomarkers. The objectives were to evaluate the expression of Ki-67, Cornulin and ISG15 in non-involved mucosal surgical margins and the association of clinicopathological prognosticators with local relapse in oral squamous cell carcinoma. Methods Surgical margins from the study (relapse) group (n = 23), control (non-relapse) group (n = 32) and normal oral mucosa (n = 5) were immunohistochemically stained using Ki-67, Cornulin and ISG15 antibodies. Association between expression of markers and clinicopathological prognosticators with local relapse in oral squamous cell carcinoma was analyzed statistically. Results The study group surgical margins demonstrated significantly decreased Cornulin expression (p = 0.032). Low Cornulin expression was significantly associated with local relapse (p = 0.004) and non-tongue primary tumor (p = 0.013). Although not significantly associated with local relapse, expression of Ki-67 was significantly reduced in female patients (p = 0.041). Age above 57.5 years, Chinese & Indian ethnicity, alcohol consumption, epithelial dysplasia in surgical margins, and type III and IV patterns of invasion of tumor were also significantly related to local relapse. Regression analysis showed low expression of Cornulin (p = 0.018), and increased patient's age (p = 0.008) were predictors of local relapse in oral squamous cell carcinoma, with 34-fold risk and 18-fold risk, respectively. Expression of Ki-67 and ISG15 did not show significant association with local relapse in oral squamous cell carcinoma. Conclusion Low expression of Cornulin is an independent predictor of relapse in oral squamous cell carcinoma.
| Item Type: | Article |
|---|---|
| Funders: | University of Malaya Dental Postgraduate Research Grant (DPRG)[DPRG/10/17], MAHSA research grant[RP138/02-18] |
| Uncontrolled Keywords: | Field cancerization;Cancer;Recurrence;Gene;Prognosis;Survival |
| Subjects: | R Medicine R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) R Medicine > RD Surgery R Medicine > RK Dentistry |
| Divisions: | Faculty of Dentistry |
| Depositing User: | Ms Zaharah Ramly |
| Date Deposited: | 18 Oct 2022 05:40 |
| Last Modified: | 18 Oct 2022 05:40 |
| URI: | http://eprints.um.edu.my/id/eprint/35263 |
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