Saif-Ali, R. and Muniandy, S. and Al-Hamodi, Z. and Lee, C.S. and Ahmed, K.A. and Al-Mekhlafi, A.M. and Ismail, I.S. (2011) KCNQ1 variants associate with type 2 diabetes in Malaysian Malay subjects. Annals of the Academy of Medicine, Singapore, 40 (11). ISSN 0304-4602, DOI PMID: 22206064.
Full text not available from this repository.Abstract
INTRODUCTION: Type 2 diabetes (T2D) candidate gene: potassium voltage-gated channel, KQT-like subfamily, member 1 (KCNQ1) was suggested by conducting a genome wide association study (GWAS) in Japanese population. Association studies have been replicated among East Asian populations; however, the association between this gene and T2D in Southeast Asian populations still needs to be studied. This study aimed to investigate the association of KCNQ1 common variants with type 2 diabetes in Malaysian Malay subjects. MATERIALS AND METHODS: The KCNQ1 single nucleotide polymorphisms (SNPs): rs2237892, rs2283228, and rs2237895 were genotyped in 234 T2D and 177 normal Malay subjects. RESULTS: The risk allele of the rs2283228 (A) was strongly associated with T2D (OR = 1.7, P = 0.0006) while the rs2237892 (C) was moderately associated with T2D (OR = 1.45, P = 0.017). The recessive genetic models showed that rs2283228 was strongly associated with T2D (OR = 2.35, P = 0.00005) whereas rs2237892 showed a moderate association with T2D (OR = 1.69, P = 0.01). The haplotype block (TCA), which contained the protective allele, correlated with a protection from T2D (OR = 0.5, P = 0.003). Furthermore, the diplotype (CAA-TCA) that contained the protective haplotype was protected against T2D (OR = 0.46, P = 0.006). CONCLUSION: The KCNQ1 SNPs, haplotypes and diplotypes are associated with T2D in the Malaysian Malay subjects.
| Item Type: | Article |
|---|---|
| Funders: | UNSPECIFIED |
| Additional Information: | Department of Molecular Medicine, Faculty of Medicine, University Malaya, Malaysia. reyadh70@yahoo.com |
| Uncontrolled Keywords: | Molecular Medicine; Adult; Diabetes Mellitus, Type 2/ethnology; Diabetes Mellitus, Type 2/genetics |
| Subjects: | R Medicine |
| Divisions: | Faculty of Medicine |
| Depositing User: | Mr. Faizal Hamzah |
| Date Deposited: | 04 Jul 2012 01:28 |
| Last Modified: | 04 Jul 2012 01:28 |
| URI: | http://eprints.um.edu.my/id/eprint/3468 |
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