Salmon, Charlotte and Song, Lixin and Muir, Kenneth and Pashayan, Nora and Dunning, Alison M. and Batra, Jyotsna and Chambers, Suzanne and Stanford, Janet L. and Ostrander, Elaine A. and Park, Jong Y. and Lin, Hui-Yi and Cussenot, Olivier and Cancel-Tassin, Geraldine and Menegaux, Florence and Cordina-Duverger, Emilie and Kogevinas, Manolis and Llorca, Javier and Kaneva, Radka and Slavov, Chavdar and Razack, Azad and Lim, Jasmine and Gago-Dominguez, Manuela and Castelao, Jose Esteban and Kote-Jarai, Zsofia and Eeles, Rosalind A. and Parent, Marie-Elise and Collaborators, UKGPCS and Pros, APCB BioResource Australian and Consortium, PRACTICAL (2021) Marital status and prostate cancer incidence: A pooled analysis of 12 case-control studies from the PRACTICAL consortium. European Journal of Epidemiology, 36 (9). pp. 913-925. ISSN 0393-2990, DOI https://doi.org/10.1007/s10654-021-00781-1.
Full text not available from this repository.Abstract
While being in a committed relationship is associated with a better prostate cancer prognosis, little is known about how marital status relates to its incidence. Social support provided by marriage/relationship could promote a healthy lifestyle and an increased healthcare seeking behavior. We investigated the association between marital status and prostate cancer risk using data from the PRACTICAL Consortium. Pooled analyses were conducted combining 12 case-control studies based on histologically-confirmed incident prostate cancers and controls with information on marital status prior to diagnosis/interview. Marital status was categorized as married/partner, separated/divorced, single, or widowed. Tumours with Gleason scores >= 8 defined high-grade cancers, and low-grade otherwise. NCI-SEER's summary stages (local, regional, distant) indicated the extent of the cancer. Logistic regression was used to derive odds ratios (ORs) and 95% confidence intervals (CI) for the association between marital status and prostate cancer risk, adjusting for potential confounders. Overall, 14,760 cases and 12,019 controls contributed to analyses. Compared to men who were married/with a partner, widowed men had an OR of 1.19 (95% CI 1.03-1.35) of prostate cancer, with little difference between low- and high-grade tumours. Risk estimates among widowers were 1.14 (95% CI 0.97-1.34) for local, 1.53 (95% CI 1.22-1.92) for regional, and 1.56 (95% CI 1.05-2.32) for distant stage tumours. Single men had elevated risks of high-grade cancers. Our findings highlight elevated risks of incident prostate cancer among widowers, more often characterized by tumours that had spread beyond the prostate at the time of diagnosis. Social support interventions and closer medical follow-up in this sub-population are warranted.
| Item Type: | Article |
|---|---|
| Funders: | Canadian Institutes of Health Research (CIHR), European Commission European Commission Joint Research Centre[223175], Cancer Research UK[C5047/A7357], Institute of Cancer Research, Prostate Cancer Research Foundation |
| Uncontrolled Keywords: | Marital status;Prostate cancer;Consortium;Pooled analysis; Meta-analysis |
| Subjects: | R Medicine R Medicine > RA Public aspects of medicine R Medicine > RC Internal medicine R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) |
| Depositing User: | Ms Zaharah Ramly |
| Date Deposited: | 15 Sep 2022 08:15 |
| Last Modified: | 15 Sep 2022 08:15 |
| URI: | http://eprints.um.edu.my/id/eprint/34656 |
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